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| Accession Number: | Q68KI4 |
| Protein Name: | Sodium/hydrogen exchanger 1 |
| Length: | 538 |
| Molecular Weight: | 59513.00 |
| Species: | [3702] |
| Number of TMSs: | 12 |
| Location1 / Topology2 / Orientation3: | Vacuole membrane1 / Multi-pass membrane protein2 |
| Substrate | lithium(1+), sodium(1+), potassium(1+), caesium(1+), hydron |
Cross database links:
| RefSeq: | NP_198067.1 |
|---|---|
| Entrez Gene ID: | 832773 |
| Pfam: | PF00999 |
| KEGG: | ath:AT5G27150 |
Gene Ontology
GO:0005789
C:endoplasmic reticulum membrane
GO:0000139
C:Golgi membrane
GO:0016021
C:integral to membrane
GO:0000325
C:plant-type vacuole
GO:0005886
C:plasma membrane
GO:0005774
C:vacuolar membrane
GO:0005516
F:calmodulin binding
GO:0015081
F:sodium ion transmembrane transporter activity
GO:0015385
F:sodium:hydrogen antiporter activity
GO:0048366
P:leaf development
GO:0010351
P:lithium ion transport
GO:0006885
P:regulation of pH
GO:0009651
P:response to salt stress
GO:0006814
P:sodium ion transport
GO:0055085
P:transmembrane transport
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References (14)[1] “The Arabidopsis thaliana proton transporters, AtNhx1 and Avp1, can function in cation detoxification in yeast.” Gaxiola R.A.et.al. 9990049 [2] “Functional conservation between yeast and plant endosomal Na(+)/H(+) antiporters.” Quintero F.J.et.al. 10767428 [3] “Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.” Tabata S.et.al. 11130714 [4] “Salt tolerance conferred by overexpression of a vacuolar Na(+)/H(+) antiport in Arabidopsis.” Apse M.P.et.al. 10455050 [5] “Arabidopsis thaliana and Saccharomyces cerevisiae NHX1 genes encode amiloride sensitive electroneutral Na(+)/H(+) exchangers.” Darley C.P.et.al. 10998367 [6] “Engineering salt-tolerant Brassica plants: characterization of yield and seed oil quality in transgenic plants with increased vacuolar sodium accumulation.” Zhang H.-X.et.al. 11606781 [7] “The Arabidopsis Na(+)/H(+) exchanger AtNHX1 catalyzes low affinity Na(+) and K(+) transport in reconstituted liposomes.” Venema K.et.al. 11707435 [8] “Differential expression and function of Arabidopsis thaliana NHX Na(+)/H(+) antiporters in the salt stress response.” Yokoi S.et.al. 12047628 [9] “Regulation of expression of the vacuolar Na(+)/H(+) antiporter gene AtNHX1 by salt stress and abscisic acid.” Shi H.et.al. 12369629 [10] “Vacuolar cation/H(+) exchange, ion homeostasis, and leaf development are altered in a T-DNA insertional mutant of AtNHX1, the Arabidopsis vacuolar Na(+)/H(+) antiporter.” Apse M.P.et.al. 14535887 [11] “Topological analysis of a plant vacuolar Na(+)/H(+) antiporter reveals a luminal C-terminus that regulates antiporter cation selectivity.” Yamaguchi T.et.al. 14530406 [12] “Expression of an Arabidopsis vacuolar sodium/proton antiporter gene in cotton improves photosynthetic performance under salt conditions and increases fiber yield in the field.” He C.et.al. 16179357 [13] “Vacuolar Na(+)/H(+) antiporter cation selectivity is regulated by calmodulin from within the vacuole in a Ca2(+)- and pH-dependent manner.” Yamaguchi T.et.al. 16249341 [14] “Large-scale Arabidopsis phosphoproteome profiling reveals novel chloroplast kinase substrates and phosphorylation networks.” Reiland S.et.al. 19376835
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External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MLDSLVSKLP SLSTSDHASV VALNLFVALL CACIVLGHLL EENRWMNESI TALLIGLGTG 61: VTILLISKGK SSHLLVFSED LFFIYLLPPI IFNAGFQVKK KQFFRNFVTI MLFGAVGTII 121: SCTIISLGVT QFFKKLDIGT FDLGDYLAIG AIFAATDSVC TLQVLNQDET PLLYSLVFGE 181: GVVNDATSVV VFNAIQSFDL THLNHEAAFH LLGNFLYLFL LSTLLGAATG LISAYVIKKL 241: YFGRHSTDRE VALMMLMAYL SYMLAELFDL SGILTVFFCG IVMSHYTWHN VTESSRITTK 301: HTFATLSFLA ETFIFLYVGM DALDIDKWRS VSDTPGTSIA VSSILMGLVM VGRAAFVFPL 361: SFLSNLAKKN QSEKINFNMQ VVIWWSGLMR GAVSMALAYN KFTRAGHTDV RGNAIMITST 421: ITVCLFSTVV FGMLTKPLIS YLLPHQNATT SMLSDDNTPK SIHIPLLDQD SFIEPSGNHN 481: VPRPDSIRGF LTRPTRTVHY YWRQFDDSFM RPVFGGRGFV PFVPGSPTER NPPDLSKA