2.A.36.5.8
Sodium/hydrogen exchanger 4, NHX4, of 529 aas and 8 TMSs. This endosomal protein is critical for salt tolerance in cotton (Ma et al. 2020). It probably acts as a low affinity electroneutral exchanger of protons for cations such as Na+ or K+ across membranes, but may also exchange Li+ and Cs+ with lower affinities.
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| Accession Number: | Q8S397 |
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| Protein Name: | Sodium/hydrogen exchanger 4 |
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| Length: | 529 |
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| Molecular Weight: | 58872.00 |
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| Species: | Arabidopsis thaliana (Mouse-ear cress) [3702] |
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| Number of TMSs: | 12 |
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| Location1 / Topology2 / Orientation3: |
Vacuole membrane1 / Multi-pass membrane protein2 |
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| Substrate |
lithium(1+), sodium(1+), potassium(1+), caesium(1+), hydron |
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1: MSIGLTEFVT NKLAAEHPQV IPISVFIAIL CLCLVIGHLL EENRWVNESI TAILVGAASG
61: TVILLISKGK SSHILVFDEE LFFIYLLPPI IFNAGFQVKK KKFFHNFLTI MSFGVIGVFI
121: STVIISFGTW WLFPKLGFKG LSARDYLAIG TIFSSTDTVC TLQILHQDET PLLYSLVFGE
181: GVVNDATSVV LFNAVQKIQF ESLTGWTALQ VFGNFLYLFS TSTLLGIGVG LITSFVLKTL
241: YFGRHSTTRE LAIMVLMAYL SYMLAELFSL SGILTVFFCG VLMSHYASYN VTESSRITSR
301: HVFAMLSFIA ETFIFLYVGT DALDFTKWKT SSLSFGGTLG VSGVITALVL LGRAAFVFPL
361: SVLTNFMNRH TERNESITFK HQVIIWWAGL MRGAVSIALA FKQFTYSGVT LDPVNAAMVT
421: NTTIVVLFTT LVFGFLTKPL VNYLLPQDAS HNTGNRGKRT EPGSPKEDAT LPLLSFDESA
481: STNFNRAKDS ISLLMEQPVY TIHRYWRKFD DTYMRPIFGG PRRENQPEC