2.A.36.5.9 The sodium/hydrogen exchanger 2, NHX2, of 546 aas and 13 TMSs. It catalyzes the low affinity electroneutral exchange of protons for cations such as Na+ or K+ across membranes, and may also exchange Li+ and Cs+ with a lower affinity. It is involved in vacuolar ion compartmentalization necessary for cell volume regulation and cytoplasmic Na+ detoxification (Yokoi et al. 2002). Its ortholog has also been studied in Phyllostachys edulis (moso bamboo) where its overexpression reduces salt tolerance (Wu et al. 2021).
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Accession Number: | Q56XP4 |
Protein Name: | Sodium/hydrogen exchanger 2 |
Length: | 546 |
Molecular Weight: | 60523.00 |
Species: | Arabidopsis thaliana (Mouse-ear cress) [3702] |
Number of TMSs: | 13 |
Location1 / Topology2 / Orientation3: |
Vacuole membrane1 / Multi-pass membrane protein2 |
Substrate |
lithium(1+), sodium(1+), potassium(1+), caesium ion, hydron |
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1: MTMFASLTSK MLSVSTSDHA SVVSLNLFVA LLCACIVIGH LLEENRWMNE SITALLIGLG
61: TGVVILLISR GKNSHLLVFS EDLFFIYLLP PIIFNAGFQV KKKQFFRNFV TIMAFGAIGT
121: VVSCTIISLG AIQFFKKLDI GTFDLGDFLA IGAIFAATDS VCTLQVLNQD ETPLLYSLVF
181: GEGVVNDATS VVLFNAIQSF DLTHLNHEAA FQFLGNFFYL FLLSTGLGVA TGLISAYVIK
241: KLYFGRHSTD REVALMMLMA YLSYMLAELF ALSGILTVFF CGIVMSHYTW HNVTESSRIT
301: TKHAFATLSF LAETFIFLYV GMDALDIEKW RFVSDSPGTS VAVSSILMGL VMLGRAAFVF
361: PLSFLSNLAK KHQSEKISIK QQVVIWWAGL MRGAVSMALA YNKFTRSGHT ELRGNAIMIT
421: STITVCLFST MVFGMLTKPL IRYLMPHQKA TTSTTSMLSD DSTPKSIHIP LLDGEQLDSF
481: ELPGSHQDVP RPNSLRGFLM RPTRTVHYYW RQFDDAFMRP VFGGRGFVPF VPGSPTERSS
541: HDLSKP