2.A.36.7.7
Testis-specific sodium:proton exchanger, mtsNHE (Slc9c1) of 1175 aas and 12 - 16 TMSs. It is present in sperm flagellae and seems to be required for optimal sperm motility, fertilization and the acrosome reaction (Liu et al. 2010). 69% identical to the human NHE, TC# 2.A.36.7.5. It may have a 12 TMS topology, but has a long C-terminal hydrophilic domain with a segment showing 2 - 4 TMSs.
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| Accession Number: | Q6UJY2 |
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| Protein Name: | Sodium/hydrogen exchanger 10 |
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| Length: | 1175 |
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| Molecular Weight: | 135545.00 |
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| Species: | Mus musculus (Mouse) [10090] |
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| Number of TMSs: | 13 |
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| Location1 / Topology2 / Orientation3: |
Cell projection1 / Multi-pass membrane protein2 |
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| Substrate |
sodium(1+), hydron |
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1: MEMEEISENL TASHSIKLTN MWLELLKSVF LSTPQDLPEI ILILSLICTV GAFLNMHLKD
61: FPIPLPVILF LIGCCFEILS FASTQIQIYA DAIQWMDPDI FFGIFTPVII FNVAFDMDIY
121: MLQKLFWQIL VITIPGFLIN YTLILWYLQS VNKLSLKTVP WLLFSAVLIS SDPMLTSASI
181: RDLGLSRSLT NLINGESLLT SVLSLVIYSG VVHIRFKSKS VNHTLAHKVM STAWSYIVES
241: FITGIVFTKV IQLWMATIFG DDVNHITLIF SVLYLIFYVC ELVGMSGIFT LATIGLFLNS
301: TSFKPGVEAF LLEFWNCLSF IGFLMVFTFI GLLIPAHTYL HISFSDVYYS LNIYFTLIVL
361: RLLVFLLMSP ILSRLGHGFS WRWAFIMVWS EMKGTPNINM ALLLAYSDIS LGSERERSQI
421: LFHGVSVCVI TLIVNRFILP MAVTKLGLRD VTSTKYKSVY YTFQHFQELT KSTAMALKFD
481: KDLANADWNM VDNAIILQNP YAMNQEEITE HQKVKCPDCN KEIDETLNIE AMELTNRRLL
541: SAQIASYQRQ YRNEVLSQSA VQVLVGAAGS FGEKKGEYMS PENIKNFSES KKLLSFLRKL
601: LLNWVYNTKK DKGVPSRYMF LHACHRIVFT NEFEYTGYLV VLMSTYPMII CWISRLKDIY
661: DNEIKCANYY FLAFYILEAL LKVAAMRKEF FSHTWLLFEL GITLVGVLDI ILIETDSISY
721: NFDLTETVVF MNVIRLLRIL RILKLVTPKL LQIIDKRMSQ QISFRYSILK GYVQGEMDVL
781: NIIDQIASSK QTKQILLKRV MRNMEHAMKE LGYLEYDHPE IAVTMKTKEE INVMLNMARE
841: IVKAFRSKGI IHKVEGTEIN KLIMAKKIQV LDLQSVIQPF NVEEAPCNIP WLSEDPEAIT
901: FIQEKAKVVT FDCGNNIFEE GDEPEGIYVI ISGMVKLKRS KPHLEMERVS AESEIKIHPL
961: PHTEYLLSGE IIGELNCLTK ERMQYSATCK TVVETYFIPI SHLYEGFEKR CPNMKHKMWQ
1021: KIGLAITAQK IREHLSFEDW NYKLQLKLCN AFIRDIPKSM KTDIYDETVT HVVLIHGSAE
1081: DCQLRKIYKA PFLIPVTCHQ IQGMEDFTKV MIIQTSIAVR KFRWNVRKYI PPRRISMKPD
1141: SERESFETLD ETSEEDNGKK ENQENEELIE ENINI