2.A.4.2.6
Zinc transporter 1 (ZnT-1 or ZnT1) (Solute carrier family 30 member 1). The loss of the sialic acid transporter SLC35A1/CST (TC# 2.A.7.12.11) and the zinc transporter, ZnT1, affected cell survival upon infection with cytolytic vesicular stomatitis virus (VSV). Both of these transporters seem to play a role in the apoptotic response induced by VSV (Moskovskich et al. 2019). ZnT1 functions by Zn²⁺:H⁺ antiport and has a C-terminal hydrophilic domain that is a dimer in solution with a V-shaped core (Cotrim et al. 2021). There are 10 ZnT proteins in humans, but only ZnT1 is a zinc exporter in the plasma membrane, and only ZnT10 is a Mn²⁺ exporter; a reliable in vitro assay has been developed for measuring Zn²⁺ uptake (Ben Yosef et al. 2023).  Somatic SLC30A1 mutations altering zinc transporter ZnT1 cause aldosterone-producing adenomas and primary aldosteronism (Rege et al. 2023).  Human ZnT1 is a Zn²⁺/Ca²⁺ exchanger with a known cryo-EM structure. hZnT1 has a homodimeric structure, and each subunit contains a transmembrane domain consisting of six transmembrane segments, a cytosolic domain, and an extracellular domain. The transmembrane region displays an outward-facing conformation (Sun et al. 2024).