2.A.4.3.12
Zinc transporter, Ttm-1, of 410 aas and 6 TMSs in a 2 + 2 + 2 TMS arrangement. It promotes excretion of zinc from intestinal cells into the intestinal lumen in response to increased dietary zinc (Roh et al. 2013). It is also involved in cadmium resistance, possibly by promoting its transport from cells (Huffman et al. 2004).
It is also involved in resistance to B. thuringiensis pore-forming toxin Cry5B
downstream of the sek-1 and pmk-1 MAPK kinase pathway.
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| Accession Number: | O45923 |
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| Protein Name: | Zinc transporter ttm-1 |
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| Length: | 410 |
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| Molecular Weight: | 44082.00 |
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| Species: | Caenorhabditis elegans [6239] |
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| Number of TMSs: | 6 |
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| Location1 / Topology2 / Orientation3: |
Apical cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
cadmium(2+), zinc(2+) |
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1: MTISMISPSS IRLSSDKRDS SSSNLPANIE EDTQSVSSSD SGVSADSIDH HHHGHGHGHS
61: HGGHGHSHTH NNDDSSSDCS GAGGGAHKHS HDEKYQKGRR AEKVLWAVAA LSAVFIAAEF
121: VGGFWAQSLA IMTDAGHMLS DLLSFIISIF AIRCARLPAS KRLSFGYERA EVLGALTSVI
181: ILWVLTTVLV VVAIQRIVNN EHEVDADVML ITAGVGVLFN IVMGLVLHFG TGGHGHTHGG
241: HSSHGHAHDG KNVNVRAALI HVIGDLVQSI GVLIAALIIR FTGWTLADPI CTFLFSIIVL
301: FTTVTVMRDI FFVLMEATPS HYDLSDVKKA LSALEGVKGV HDLHLWSIGM DKTAFSVHLA
361: LESPNRAMEN VAEARSLIRR RFGVAVATVQ VEPFDEKIDS CDTCQQQETA