2.A.4.3.13
Zn2+, Fe2+ and Co2+ exporter, AitP, of 321 aas and 6 TMSs. The N2-fixing bacteria, Sinorhizobium meliloti, is a suitable model to determine the roles of Co2+-transporting Co-eCDF in Fe2+ homeostasis because it has a putative member of this subfamily, AitP, and two specific Fe2+-export systems. An insertional mutant of AitP showed Co2+ sensitivity and accumulation, Fe accumulation and hydrogen peroxide sensitivity, but not Fe2+ sensitivity, despite AitP being a bona fide low affinity Fe2+ exporter as demonstrated by the kinetic analyses of Fe2+ uptake into everted membrane vesicles (Mihelj et al. 2023).
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| Accession Number: | Q92P03 |
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| Protein Name: | Cation transporter |
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| Length: | 321 |
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| Molecular Weight: | 35038.00 |
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| Species: | Rhizobium meliloti (strain 1021) (Ensifer meliloti) [266834] |
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| Number of TMSs: | 6 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
cobalt(2+), iron(2+), zinc(2+) |
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1: MSETHSPAPA GHDHVFLGDN HQRNERRTWF VIALTAGMMV AEIAAGTFYG SMALVADGWH
61: MSTHAAALLI AALAYLYARR NARNPRFTFG TGKLGDLAGF SSAIVLALIA LLIGWESLLR
121: LANPVAISFP QAISVAVLGL AVNLACAWLL REDHSHHHHG HHHHGHHHHH EHHHSVSAHG
181: RDNNLRAAYL HVLADALTSV LAIVALAAGS VYGWIWLDPM MGIVGALVIA RWSWGLIRDS
241: GSVLLDYIPP GEDLPDEIRA AIERDGDRIT DLHVWQLGPG HHGAIVSLVT KNPQSPSTYR
301: RKLEHIHELS HVTVEVEPLA A