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2.A.4.3.2
Vesicular Zn2+ uptake (into synaptic vesicles) permease, ZnT3 (SLC30A subfamily). ZnT-3 regulates presynaptic Erk1/2 signaling and hippocampus-dependent memory (Sindreu et al., 2011). Cryo-EM structures of the zinc transporters ZnT3 and ZnT4 provide insights into their transport mechanisms (Ishida et al. 2024).

Accession Number:Q99726
Protein Name:Zinc transporter 3 aka ZnT-3
Length:388
Molecular Weight:41945.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Cytoplasmic vesicle1 / Multi-pass membrane protein2
Substrate zinc(2+)

Cross database links:

RefSeq: NP_003450.2   
Entrez Gene ID: 7781   
Pfam: PF01545   
OMIM: 602878  gene
KEGG: hsa:7781    hsa:7781   

Gene Ontology

GO:0030054 C:cell junction
GO:0005887 C:integral to plasma membrane
GO:0005770 C:late endosome
GO:0005624 C:membrane fraction
GO:0030672 C:synaptic vesicle membrane
GO:0015633 F:zinc transporting ATPase activity
GO:0032119 P:sequestering of zinc ion
GO:0055085 P:transmembrane transport
GO:0006829 P:zinc ion transport
GO:0008021 C:synaptic vesicle
GO:0051050 P:positive regulation of transport
GO:0061088 P:regulation of sequestering of zinc ion

References (8)

[1] “ZnT-3, a putative transporter of zinc into synaptic vesicles.”  Palmiter R.D.et.al.   8962159
[2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[3] “Generation and annotation of the DNA sequences of human chromosomes 2 and 4.”  Hillier L.W.et.al.   15815621
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “ZnT-3, a putative transporter of zinc into synaptic vesicles.”  Palmiter R.D.et.al.   8962159
[6] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[7] “Generation and annotation of the DNA sequences of human chromosomes 2 and 4.”  Hillier L.W.et.al.   15815621
[8] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MEPSPAAGGL ETTRLVSPRD RGGAGGSLRL KSLFTEPSEP LPEESKPVEM PFHHCHRDPL 
61:	PPPGLTPERL HARRQLYAAC AVCFVFMAGE VVGGYLAHSL AIMTDAAHLL ADVGSMMGSL 
121:	FSLWLSTRPA TRTMTFGWHR SETLGALASV VSLWMVTGIL LYLAFVRLLH SDYHIEGGAM 
181:	LLTASIAVCA NLLMAFVLHQ AGPPHSHGSR GAEYAPLEEG PEEPLPLGNT SVRAAFVHVL 
241:	GDLLQSFGVL AASILIYFKP QYKAADPIST FLFSICALGS TAPTLRDVLR ILMEGTPRNV 
301:	GFEPVRDTLL SVPGVRATHE LHLWALTLTY HVASAHLAID STADPEAVLA EASSRLYSRF 
361:	GFSSCTLQVE QYQPEMAQCL RCQEPPQA