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2.A.4.3.3 Mammary epithelia/brain Zn²⁺ transporter ZnT4 (the cause of inherited zinc deficiency in the lethal milk (lm) syndrome of mice, due to a nonsense mutation at codon 297 (arg) in the ZnT4 gene) (Huang and Gitschier, 1997).
Accession Number:	O35149
Protein Name:	Zinc transporter 4 aka ZnT4
Length:	430
Molecular Weight:	47791.00
Species:	Mus musculus (Mouse) [10090]
Number of TMSs:	5
Location¹ / Topology² / Orientation³:	Endosome membrane¹ / Multi-pass membrane protein²
Substrate	zinc(2+)

Pfam:	PF01545
Gene Ontology GO:0010008 C:endosome membrane GO:0016021 C:integral to membrane GO:0055085 P:transmembrane transport GO:0055069 P:zinc ion homeostasis GO:0006829 P:zinc ion transport
References (1) [1] “A novel gene involved in zinc transport is deficient in the lethal milk mouse.” Huang L.et.al. 9354792

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MAGPGAWKRL KSLLRKDDTP LFLNDTSAFD FSDEVSDEGL SRFNKLRVVV ADDDSEAPER 
61:	PVNGAHPALQ ADDDSLLDQD LPLTNSQLSL KMDPCDNCSK RRELLKQRKV KTRLTIAAVL 
121:	YLLFMIGELV GGYMANSLAI MTDALHMLTD LSAIILTLLA LWLSSKSPTR RFTFGFHRLE 
181:	VLSAMISVML VYVLMGFLLY EAVQRTIHMN YEINGDVMLI TAAVGVAVNV IMGFLLNQSG 
241:	HHHSHAHSHS LPSNSPSMVS SGHNHGQDSL AVRAAFVHAL GDLVQSVGVL IAAYIIRFKP 
301:	EYKIADPICT YIFSLLVAFT TFRIIWDTVV IILEGVPSHL NVDYIKESLM KIEDVYSVED 
361:	LNIWSLTSGK STAIVHMQLI PGSSSKWEEV QSKAKHLLLN TFGMYKCTIQ LQSYRQEVIR 
421:	TCANCQSSST

2.A.4.3.3
Mammary epithelia/brain Zn²⁺ transporter ZnT4 (the cause of inherited zinc deficiency in the lethal milk (lm) syndrome of mice, due to a nonsense mutation at codon 297 (arg) in the ZnT4 gene) (Huang and Gitschier, 1997).

Cross database links:

Gene Ontology

References (1)

External Searches:

Analyze:

2.A.4.3.3Mammary epithelia/brain Zn2+ transporter ZnT4 (the cause of inherited zinc deficiency in the lethal milk (lm) syndrome of mice, due to a nonsense mutation at codon 297 (arg) in the ZnT4 gene) (Huang and Gitschier, 1997).

Cross database links:

Gene Ontology

References (1)

External Searches:

Analyze:

2.A.4.3.3
Mammary epithelia/brain Zn²⁺ transporter ZnT4 (the cause of inherited zinc deficiency in the lethal milk (lm) syndrome of mice, due to a nonsense mutation at codon 297 (arg) in the ZnT4 gene) (Huang and Gitschier, 1997).