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Accession Number: | Q8IWU4 |
Protein Name: | Zinc transporter 8 |
Length: | 369 |
Molecular Weight: | 40755.00 |
Species: | Homo sapiens (Human) [9606] |
Number of TMSs: | 7 |
Location1 / Topology2 / Orientation3: | Cell membrane1 / Multi-pass membrane protein2 |
Substrate | zinc(2+) |
Cross database links:
Entrez Gene ID: | 169026 |
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Pfam: | PF01545 |
KEGG: | hsa:169026 hsa:169026 |
Gene Ontology
GO:0016021
C:integral to membrane
GO:0005886
C:plasma membrane
GO:0030667
C:secretory granule membrane
GO:0030658
C:transport vesicle membrane
GO:0042803
F:protein homodimerization activity
GO:0008270
F:zinc ion binding
GO:0005385
F:zinc ion transmembrane transporter activity
GO:0030073
P:insulin secretion
GO:0032024
P:positive regulation of insulin secretion
GO:0061088
P:regulation of sequestering of zinc ion
GO:0060627
P:regulation of vesicle-mediated transport
GO:0009749
P:response to glucose stimulus
GO:0032119
P:sequestering of zinc ion
GO:0034341
P:response to interferon-gamma
GO:0070555
P:response to interleukin-1
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References (20)[1] “Identification and cloning of a beta-cell-specific zinc transporter, ZnT-8, localized into insulin secretory granules.” Chimienti F.et.al. 15331542 [2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [3] “The full-ORF clone resource of the German cDNA consortium.” Bechtel S.et.al. 17974005 [4] “DNA sequence and analysis of human chromosome 8.” Nusbaum C.et.al. 16421571 [5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [6] “ZnT-8, a pancreatic beta-cell-specific zinc transporter.” Chimienti F.et.al. 16158222 [7] “In vivo expression and functional characterization of the zinc transporter ZnT8 in glucose-induced insulin secretion.” Chimienti F.et.al. 16984975 [8] “Zinc-transporter genes in human visceral and subcutaneous adipocytes: lean versus obese.” Smidt K.et.al. 17118530 [9] “Intracellular zinc homeostasis in leukocyte subsets is regulated by different expression of zinc exporters ZnT-1 to ZnT-9.” Overbeck S.et.al. 17971500 [10] “A genome-wide association study identifies novel risk loci for type 2 diabetes.” Sladek R.et.al. 17293876 [11] “Identification and cloning of a beta-cell-specific zinc transporter, ZnT-8, localized into insulin secretory granules.” Chimienti F.et.al. 15331542 [12] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [13] “The full-ORF clone resource of the German cDNA consortium.” Bechtel S.et.al. 17974005 [14] “DNA sequence and analysis of human chromosome 8.” Nusbaum C.et.al. 16421571 [15] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [16] “ZnT-8, a pancreatic beta-cell-specific zinc transporter.” Chimienti F.et.al. 16158222 | |
Structure: | |
External Searches:
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Analyze:
Predict TMSs (Predict number of transmembrane segments) | ||||
FASTA formatted sequence |
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1: MEFLERTYLV NDKAAKMYAF TLESVELQQK PVNKDQCPRE RPEELESGGM YHCHSGSKPT 61: EKGANEYAYA KWKLCSASAI CFIFMIAEVV GGHIAGSLAV VTDAAHLLID LTSFLLSLFS 121: LWLSSKPPSK RLTFGWHRAE ILGALLSILC IWVVTGVLVY LACERLLYPD YQIQATVMII 181: VSSCAVAANI VLTVVLHQRC LGHNHKEVQA NASVRAAFVH ALGDLFQSIS VLISALIIYF 241: KPEYKIADPI CTFIFSILVL ASTITILKDF SILLMEGVPK SLNYSGVKEL ILAVDGVLSV 301: HSLHIWSLTM NQVILSAHVA TAASRDSQVV RREIAKALSK SFTMHSLTIQ MESPVDQDPD 361: CLFCEDPCD