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2.A.4.8.3
Zn2+ transporter, TMEM163 or Znt11, of 289 aas and 6 TMSs.  Interacts with TrpML1 (TC# 1.A.5.3.1), but by itself, it can pump out Zn2+ (Sanchez et al. 2019).  It may be involved in the human lipid storage disorder, mucolipidosis type IV (MLIV), caused by Zn2+ overload (Cuajungco et al. 2014). TMEM163 is found in synaptic vesicles where it is called SV31 (Burré et al. 2007). It plays a role in Zn2+ uptake into lysosomes (Cuajungco and Kiselyov 2017) TMEM163 proteins catalyze Zn2+ efflux from cells and are critical for the biogenesis of platelet dense granules in mice (Yuan et al. 2021). TMEM163's discovery, transport feature, protein interactome, and similarities, as well as differences, with known SLC30 (ZnT) protein family members have been reviewed (Styrpejko and Cuajungco 2021). They also examined recent reports that implicate TMEM163 directly or indirectly in various human diseases such as Parkinson's disease, Mucolipidosis type IV and diabetes. TMEM163 is a dimer that catalyzes Zn2+ efflux from cells, or uptake into intracellular vesicles including lysosomes.

Accession Number:Q8TC26
Protein Name:Transmembrane protein 163
Length:289
Molecular Weight:31469.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Cytoplasmic vesicle1 / Multi-pass membrane protein2
Substrate zinc(2+)

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FASTA formatted sequence
1:	MEPAAGIQRR SSQGPTVPPP PRGHAPPAAA PGPAPLSSPV REPPQLEEER QVRISESGQF 
61:	SDGLEDRGLL ESSTRLKPHE AQNYRKKALW VSWFSIIVTL ALAVAAFTVS VMRYSASAFG 
121:	FAFDAILDVL SSAIVLWRYS NAAAVHSAHR EYIACVILGV IFLLSSICIV VKAIHDLSTR 
181:	LLPEVDDFLF SVSILSGILC SILAVLKFML GKVLTSRALI TDGFNSLVGG VMGFSILLSA 
241:	EVFKHDSAVW YLDGSIGVLI GLTIFAYGVK LLIDMVPRVR QTRHYEMFE