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2.A.40.1.3 Pyrimidine transporter of broad specificity, RutG of 442 aas and 14 TMSs; transports both uracil and thymine with high affinity as well as, xanthine with low efficiency (Loh et al., 2006; Kim et al. 2010; Botou et al. 2018).
Accession Number:	P75892
Protein Name:	RutG
Length:	442
Molecular Weight:	45557.00
Species:	Escherichia coli (strain K12) [83333]
Number of TMSs:	14
Location¹ / Topology² / Orientation³:	Cell inner membrane¹ / Multi-pass membrane protein²
Substrate	pyrimidine

RefSeq:	AP_001637.1 NP_415526.4
Entrez Gene ID:	946589
Pfam:	PF00860
BioCyc:	EcoCyc:B1006-MONOMER ECOL168927:B1006-MONOMER
KEGG:	ecj:JW5137 eco:b1006
Gene Ontology GO:0016021 C:integral to membrane GO:0005886 C:plasma membrane GO:0005215 F:transporter activity GO:0055085 P:transmembrane transport
References (5) [1] “A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map.” Oshima T.et.al. 8905232 [2] “The complete genome sequence of Escherichia coli K-12.” Blattner F.R.et.al. 9278503 [3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.” Hayashi K.et.al. 16738553 [4] “Global topology analysis of the Escherichia coli inner membrane proteome.” Daley D.O.et.al. 15919996 [5] “A previously undescribed pathway for pyrimidine catabolism.” Loh K.D.et.al. 16540542

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MAMFGFPHWQ LKSTSTESGV VAPDERLPFA QTAVMGVQHA VAMFGATVLM PILMGLDPNL 
61:	SILMSGIGTL LFFFITGGRV PSYLGSSAAF VGVVIAATGF NGQGINPNIS IALGGIIACG 
121:	LVYTVIGLVV MKIGTRWIER LMPPVVTGAV VMAIGLNLAP IAVKSVSASA FDSWMAVMTV 
181:	LCIGLVAVFT RGMIQRLLIL VGLIVACLLY GVMTNVLGLG KAVDFTLVSH AAWFGLPHFS 
241:	TPAFNGQAMM LIAPVAVILV AENLGHLKAV AGMTGRNMDP YMGRAFVGDG LATMLSGSVG 
301:	GSGVTTYAEN IGVMAVTKVY STLVFVAAAV IAMLLGFSPK FGALIHTIPA AVIGGASIVV 
361:	FGLIAVAGAR IWVQNRVDLS QNGNLIMVAV TLVLGAGDFA LTLGGFTLGG IGTATFGAIL 
421:	LNALLSRKLV DVPPPEVVHQ EP

2.A.40.1.3
Pyrimidine transporter of broad specificity, RutG of 442 aas and 14 TMSs; transports both uracil and thymine with high affinity as well as, xanthine with low efficiency (Loh et al., 2006; Kim et al. 2010; Botou et al. 2018).

Cross database links:

Gene Ontology

References (5)

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2.A.40.1.3Pyrimidine transporter of broad specificity, RutG of 442 aas and 14 TMSs; transports both uracil and thymine with high affinity as well as, xanthine with low efficiency (Loh et al., 2006; Kim et al. 2010; Botou et al. 2018).

Cross database links:

Gene Ontology

References (5)

External Searches:

Analyze:

2.A.40.1.3
Pyrimidine transporter of broad specificity, RutG of 442 aas and 14 TMSs; transports both uracil and thymine with high affinity as well as, xanthine with low efficiency (Loh et al., 2006; Kim et al. 2010; Botou et al. 2018).