| |
|---|---|
| Accession Number: | Q9UGH3 |
| Protein Name: | SVCT2 aka SLC23A2 |
| Length: | 650 |
| Molecular Weight: | 70337.00 |
| Species: | Homo sapiens (Human) [9606] |
| Number of TMSs: | 12 |
| Location1 / Topology2 / Orientation3: | Membrane1 / Multi-pass membrane protein2 |
| Substrate | calcium(2+), magnesium(2+), sodium(1+), L-ascorbic acid |
Cross database links:
| RefSeq: | NP_005107.4 NP_976072.1 |
|---|---|
| Entrez Gene ID: | 9962 |
| Pfam: | PF00860 |
| OMIM: |
603791 gene |
| KEGG: | hsa:9962 hsa:9962 |
Gene Ontology
GO:0016324
C:apical plasma membrane
GO:0016323
C:basolateral plasma membrane
GO:0005887
C:integral to plasma membrane
GO:0005624
C:membrane fraction
GO:0015205
F:nucleobase transmembrane transporter activity
GO:0070890
F:sodium-dependent L-ascorbate transmembrane ...
GO:0008523
F:sodium-dependent multivitamin transmembrane...
GO:0019852
P:L-ascorbic acid metabolic process
GO:0015993
P:molecular hydrogen transport
GO:0015851
P:nucleobase transport
GO:0006139
P:nucleobase, nucleoside, nucleotide and nucl...
GO:0006814
P:sodium ion transport
GO:0070904
P:transepithelial L-ascorbic acid transport
GO:0009925
C:basal plasma membrane
GO:0005737
C:cytoplasm
GO:0008520
F:L-ascorbate:sodium symporter activity
GO:0070890
F:sodium-dependent L-ascorbate transmembrane transporter activity
GO:0008523
F:sodium-dependent multivitamin transmembrane transporter activity
GO:0006139
P:nucleobase-containing compound metabolic process
GO:0006979
P:response to oxidative stress
| |
References (20)[1] “Molecular characterization of two novel transporters from human and mouse kidney and from LLC-PK1 cells reveals a novel conserved family that is homologous to bacterial and Aspergillus nucleobase transporters.” Faaland C.A.et.al. 9804989 [2] “Human placental sodium-dependent vitamin C transporter (SVCT2): molecular cloning and transport function.” Rajan D.P.et.al. 10471399 [3] “Cloning and functional characterization of the human sodium-dependent vitamin C transporters hSVCT1 and hSVCT2.” Daruwala R.C.et.al. 10556521 [4] “A human nucleobase transporter-like cDNA (SLC23A1): member of a transporter family conserved from bacteria to mammals.” Hogue D.L.et.al. 10395795 [5] “Vitamin C transport systems of mammalian cells.” Liang W.J.et.al. 11396616 [6] “Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.” Nagase T.et.al. 9039502 [7] “Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.” Nakajima D.et.al. 12168954 [8] “The DNA sequence and comparative analysis of human chromosome 20.” Deloukas P.et.al. 11780052 [9] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [10] “Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.” Mayya V.et.al. 19690332 [11] “Molecular characterization of two novel transporters from human and mouse kidney and from LLC-PK1 cells reveals a novel conserved family that is homologous to bacterial and Aspergillus nucleobase transporters.” Faaland C.A.et.al. 9804989 [12] “Human placental sodium-dependent vitamin C transporter (SVCT2): molecular cloning and transport function.” Rajan D.P.et.al. 10471399 [13] “Cloning and functional characterization of the human sodium-dependent vitamin C transporters hSVCT1 and hSVCT2.” Daruwala R.C.et.al. 10556521 [14] “A human nucleobase transporter-like cDNA (SLC23A1): member of a transporter family conserved from bacteria to mammals.” Hogue D.L.et.al. 10395795 [15] “Vitamin C transport systems of mammalian cells.” Liang W.J.et.al. 11396616 [16] “Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.” Nagase T.et.al. 9039502 [17] “Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.” Nakajima D.et.al. 12168954 [18] “The DNA sequence and comparative analysis of human chromosome 20.” Deloukas P.et.al. 11780052 [19] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [20] “Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.” Mayya V.et.al. 19690332
| |
External Searches:
|
Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
|
|||
1: MMGIGKNTTS KSMEAGSSTE GKYEDEAKHP AFFTLPVVIN GGATSSGEQD NEDTELMAIY 61: TTENGIAEKS SLAETLDSTG SLDPQRSDMI YTIEDVPPWY LCIFLGLQHY LTCFSGTIAV 121: PFLLADAMCV GYDQWATSQL IGTIFFCVGI TTLLQTTFGC RLPLFQASAF AFLAPARAIL 181: SLDKWKCNTT DVSVANGTAE LLHTEHIWYP RIREIQGAII MSSLIEVVIG LLGLPGALLK 241: YIGPLTITPT VALIGLSGFQ AAGERAGKHW GIAMLTIFLV LLFSQYARNV KFPLPIYKSK 301: KGWTAYKLQL FKMFPIILAI LVSWLLCFIF TVTDVFPPDS TKYGFYARTD ARQGVLLVAP 361: WFKVPYPFQW GLPTVSAAGV IGMLSAVVAS IIESIGDYYA CARLSCAPPP PIHAINRGIF 421: VEGLSCVLDG IFGTGNGSTS SSPNIGVLGI TKVGSRRVIQ CGAALMLALG MIGKFSALFA 481: SLPDPVLGAL FCTLFGMITA VGLSNLQFID LNSSRNLFVL GFSIFFGLVL PSYLRQNPLV 541: TGITGIDQVL NVLLTTAMFV GGCVAFILDN TIPGTPEERG IRKWKKGVGK GNKSLDGMES 601: YNLPFGMNII KKYRCFSYLP ISPTFVGYTW KGLRKSDNSR SSDEDSQATG