2.A.40.7.9
Purine transporter, PhZ, of 578 aas and probably 14 TMSs in a 2 + 4 + 2 + 2 + 4 TMS arrangement. Critical residues for transport are located in the TMSs
and an internal helix. In the latter, the A418 residue was identified as
playing a pivotal role in transport efficiency despite being far from
the putative substrate binding site, as mutant A418V showed an increased
initial uptake efficiency for the transporter´s physiological
substrates (Barraco-Vega et al. 2024).
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| Accession Number: | AOC89074.1 |
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| Protein Name: | AOC89074.1 purine transporter PhZ [Phanerodontia chrysosporium] |
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| Length: | 579 |
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| Molecular Weight: | |
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| Species: | Phanerodontia chrysosporium [2822231] |
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| Number of TMSs: | 12 |
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| Substrate |
purine nucleobase |
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1: MPIALTHRIN AFVADSPVGR WFHLEGSGHP KERVGSRFLT ELRAGLTTWA AMAYIISVNA
61: SIISDTGGTC VCTQPDLCVN DETYLSCVAD VRRDLITSTA AVSALASFLM GLLANLPVGM
121: APGLGLNAYF TYSVVGFHGS GIITYREALA AVFLEGWFFF FLSLLGLRQW LARIMPQSLV
181: MAVGAGIGLF IAFIGLSGGG LGVIGGDTTN LVGLGGCLPQ YYTSPDLPNY CASHVLQSPT
241: MWLGIFVGGV FTVFLMLYRV KGAILIGIFL TSIISWPRPT SVTYFPHTDT GDQAFDFFKQ
301: VVTFRPLKRI GNALDYNYSN GRVWYALITF LYVDILDTTG TLYSMAKFAG LRDPVTLDFE
361: NSTIAYCVDA FSISMGALMG TSPVTAFIES ATGISEGGKT GLTAITTGFA FFISVFFAPI
421: FASIPSWATG GALVIVGSLM IRNVRDINWD YVGDSVPAFL TLIIIPLTYN IAYGVIAGII
481: SFVLINGLAW ALRKVSGERF APPNYDASEP WVIPPGSIVP AWMRFIAGRT GLARDAARER
541: PADADVLEME QHAHDAASAS SLGKHVPAVA EPVTEKDD