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2.A.53.1.14
Sulfate transporter 4:1, chloroplastic, SULTR4;1, MSH12.1, of 685 aas and 13 - 15 TMSs. It is a H+/sulfate cotransporter that may play a role in the regulation of sulfate assimilation. The structure of AtSULTR4;1, in complex with SO42- at an overall resolution of 2.8 Å has been determined (Wang et al. 2021). AtSULTR4;1 forms a homodimer and has a structural fold typical of the SLC26 family of anion transporters. The bound SO42- is coordinated by side-chain hydroxyls and backbone amides, and further stabilized electrostatically by the conserved Arg393 and two helix dipoles. Proton and SO42- are co-transported, and a proton gradient significantly enhances SO42- transport. Glu347, which is ~7 Å from the bound SO42-, is required for H+-driven transport. The cytosolic STAS domain interacts with the transmembrane domains, and deletion of the STAS domain, or mutations at the interface, compromise dimer formation and reduces SO42- transport, suggesting a regulatory function of the STAS domain (Wang et al. 2021).  

Accession Number:Q9FY46
Protein Name:Sulfate transporter 4.1, chloroplastic
Length:685
Molecular Weight:75096.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Plastid1 / Multi-pass membrane protein2
Substrate sulfate

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FASTA formatted sequence
1:	MSYASLSVKD LTSLVSRSGT GSSSSLKPPG QTRPVKVIPL QHPDTSNEAR PPSIPFDDIF 
61:	SGWTAKIKRM RLVDWIDTLF PCFRWIRTYR WSEYFKLDLM AGITVGIMLV PQAMSYAKLA 
121:	GLPPIYGLYS SFVPVFVYAI FGSSRQLAIG PVALVSLLVS NALGGIADTN EELHIELAIL 
181:	LALLVGILEC IMGLLRLGWL IRFISHSVIS GFTSASAIVI GLSQIKYFLG YSIARSSKIV 
241:	PIVESIIAGA DKFQWPPFVM GSLILVILQV MKHVGKAKKE LQFLRAAAPL TGIVLGTTIA 
301:	KVFHPPSISL VGEIPQGLPT FSFPRSFDHA KTLLPTSALI TGVAILESVG IAKALAAKNR 
361:	YELDSNSELF GLGVANILGS LFSAYPATGS FSRSAVNNES EAKTGLSGLI TGIIIGCSLL 
421:	FLTPMFKYIP QCALAAIVIS AVSGLVDYDE AIFLWRVDKR DFSLWTITST ITLFFGIEIG 
481:	VLVGVGFSLA FVIHESANPH IAVLGRLPGT TVYRNIKQYP EAYTYNGIVI VRIDSPIYFA 
541:	NISYIKDRLR EYEVAVDKYT NRGLEVDRIN FVILEMSPVT HIDSSAVEAL KELYQEYKTR 
601:	DIQLAISNPN KDVHLTIARS GMVELVGKEW FFVRVHDAVQ VCLQYVQSSN LEDKHLSFTR 
661:	RYGGSNNNSS SSNALLKEPL LSVEK