Search TCDB: (?)
TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.53.2.10
The anion exchanger, channel and Na+-transporter, SLC26a9 (Chang et al. 2009). Differential contributions and interactions of SLC26A9 with CFTR to Cl- conductance in polarized and non-polarized epithelial cells have been demonstrated (Ousingsawat et al., 2012). Slc26a9 (-/-) mice have reduced gastric acid secretion (Chen et al., 2012). Polymorphisms in the human orthologue lead to altered activity and levels (Chen et al., 2012).  SLC26A9 is subjected to endoplasmic reticulum associated degradation (ERAD) via Hsp70-dependent targeting of the soluble STAS domain (Needham et al. 2021).  SLC26A9 modifies rapidly progressing cystic fibrosis associated with the homozygous F508del CFTR mutation (Luo et al. 2024).

Accession Number:Q8BU91
Protein Name:Solute carrier family 26 member 9
Length:790
Molecular Weight:86852.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate anion, sodium(1+)

Cross database links:

RefSeq: NP_796217.2   
Entrez Gene ID: 320718   
Pfam: PF01740    PF00916   
KEGG: mmu:320718   

Gene Ontology

GO:0016324 C:apical plasma membrane
GO:0016021 C:integral to membrane
GO:0015301 F:anion:anion antiporter activity
GO:0015106 F:bicarbonate transmembrane transporter activity
GO:0008271 F:secondary active sulfate transmembrane tran...
GO:0015701 P:bicarbonate transport
GO:0006821 P:chloride transport
GO:0006885 P:regulation of pH
GO:0008272 P:sulfate transport
GO:0055085 P:transmembrane transport

References (3)

[1] “The transcriptional landscape of the mammalian genome.”  Carninci P.et.al.   16141072
[2] “SLC26A9 is expressed in gastric surface epithelial cells, mediates Cl-/HCO3- exchange, and is inhibited by NH4+.”  Xu J.et.al.   15800055
[3] “Physiology of electrogenic SLC26 paralogues.”  Romero M.F.et.al.   17120765
Structure:
6RTC   6RTF     

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence 
1:	MNQPRPRYVV DRAAYSLSLF DDEFEKKDRA YPVGEKLRNT FRCSSAKFKA FVFGLLPVLS 
61:	WLPKYKIKDY IIPDLLGGLS GGCIQVPQGM AFALLANLPA VNGLYSSFFP LLTYFFLGGI 
121:	HQMVPGTFAV ISILVGNICL QLAPESKFQI FNNVTNETYV DTAAMEAERL HVSATLACLT 
181:	AVIQMALGFM QFGFVAIYLS ESFIRGFMTA AGLQILISVL KYIFGLTIPS YTGPGSIVFT 
241:	FIDICKNLPH TNIASLIFAL VSGVFLVLVK ELNARYMHKI HFPIPTEMIV VVVATAISGS 
301:	CKMPKKYHMQ IVGEIRQGFP TPVAPMVSQW KGMVGTAFSL AIVGYVINLA MGRTLASKHG 
361:	YDVDSNQEMI ALGCSNFFGS FFKIHVICCA LSVTLAVDGA GGKSQVASLC VSLVVMITML 
421:	VLGSYLYPLP KAVLGALIAV NLKNSLKQLT DPYYLWRKSK LDCCVWVVSF LSSFFLSLPY 
481:	GVAVGVAFSI LVVIFQTQFR NGSTLAQVMD TDIYVNPKTY NRAQEIAGVK IVTYCSPLYL 
541:	ANSEIFRQKV IAKTGMDPQK VLLAKQKYLR KQEKRTAIPT QQRKSLFMKT KTVSLQELQQ 
601:	DFESAPSTDP NNNQAPAAEA HISYITFSPD ASTAAACELP ASTRSPQEAS DTLASVPPFV 
661:	TFHTLILDMS GVSFVDLMGI KALAKLSSTY EKIGVQIFLV NIHAQVYNDI SHGGVFEDGC 
721:	VQRSHVFPSI HDAVLFAQAN AREAPDRNFH GAPGDTEFSL YDSEEEGPSY WDLEQEMFGT 
781:	MFHTETLTAL