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|---|---|
| Accession Number: | Q96RN1 |
| Protein Name: | Testis anion transporter 1 |
| Length: | 970 |
| Molecular Weight: | 109006.00 |
| Species: | Homo sapiens (Human) [9606] |
| Number of TMSs: | 13 |
| Location1 / Topology2 / Orientation3: | Membrane1 / Multi-pass membrane protein2 |
| Substrate | chloride, sulfate |
Cross database links:
| Entrez Gene ID: | 116369 |
|---|---|
| Pfam: | PF01740 PF00916 |
| KEGG: | hsa:116369 hsa:116369 |
Gene Ontology
GO:0016021
C:integral to membrane
GO:0005886
C:plasma membrane
GO:0015301
F:anion:anion antiporter activity
GO:0005254
F:chloride channel activity
GO:0019531
F:oxalate transmembrane transporter activity
GO:0005515
F:protein binding
GO:0015116
F:sulfate transmembrane transporter activity
GO:0030154
P:cell differentiation
GO:0007126
P:meiosis
GO:0007275
P:multicellular organismal development
GO:0007283
P:spermatogenesis
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References (14)[1] “Tat1, a novel sulfate transporter specifically expressed in human male germ cells and potentially linked to rhogtpase signaling.” Toure A.et.al. 11278976 [2] “Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9.” Lohi H.et.al. 11834742 [3] “The DNA sequence and analysis of human chromosome 6.” Mungall A.J.et.al. 14574404 [4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [5] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [6] “Mutational analysis of the human SLC26A8 gene: exclusion as a candidate for male infertility due to primary spermatogenic failure.” Makela S.et.al. 15579655 [7] “The testis anion transporter 1 (Slc26a8) is required for sperm terminal differentiation and male fertility in the mouse.” Toure A.et.al. 17517695 [8] “Tat1, a novel sulfate transporter specifically expressed in human male germ cells and potentially linked to rhogtpase signaling.” Toure A.et.al. 11278976 [9] “Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9.” Lohi H.et.al. 11834742 [10] “The DNA sequence and analysis of human chromosome 6.” Mungall A.J.et.al. 14574404 [11] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [12] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [13] “Mutational analysis of the human SLC26A8 gene: exclusion as a candidate for male infertility due to primary spermatogenic failure.” Makela S.et.al. 15579655 [14] “The testis anion transporter 1 (Slc26a8) is required for sperm terminal differentiation and male fertility in the mouse.” Toure A.et.al. 17517695
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External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MAQLERSAIS GFSSKSRRNS FAYDVKREVY NEETFQQEHK RKASSSGNMN INITTFRHHV 61: QCRCSWHRFL RCVLTIFPFL EWMCMYRLKD WLLGDLLAGI SVGLVQVPQG LTLSLLARQL 121: IPPLNIAYAA FCSSVIYVIF GSCHQMSIGS FFLVSALLIN VLKVSPFNNG QLVMGSFVKN 181: EFSAPSYLMG YNKSLSVVAT TTFLTGIIQL IMGVLGLGFI ATYLPESAMS AYLAAVALHI 241: MLSQLTFIFG IMISFHAGPI SFFYDIINYC VALPKANSTS ILVFLTVVVA LRINKCIRIS 301: FNQYPIEFPM ELFLIIGFTV IANKISMATE TSQTLIDMIP YSFLLPVTPD FSLLPKIILQ 361: AFSLSLVSSF LLIFLGKKIA SLHNYSVNSN QDLIAIGLCN VVSSFFRSCV FTGAIARTII 421: QDKSGGRQQF ASLVGAGVML LLMVKMGHFF YTLPNAVLAG IILSNVIPYL ETISNLPSLW 481: RQDQYDCALW MMTFSSSIFL GLDIGLIISV VSAFFITTVR SHRAKILLLG QIPNTNIYRS 541: INDYREIITI PGVKIFQCCS SITFVNVYYL KHKLLKEVDM VKVPLKEEEI FSLFNSSDTN 601: LQGGKICRCF CNCDDLEPLP RILYTERFEN KLDPEASSIN LIHCSHFESM NTSQTASEDQ 661: VPYTVSSVSQ KNQGQQYEEV EEVWLPNNSS RNSSPGLPDV AESQGRRSLI PYSDASLLPS 721: VHTIILDFSM VHYVDSRGLV VLRQICNAFQ NANILILIAG CHSSIVRAFE RNDFFDAGIT 781: KTQLFLSVHD AVLFALSRKV IGSSELSIDE SETVIRETYS ETDKNDNSRY KMSSSFLGSQ 841: KNVSPGFIKI QQPVEEESEL DLELESEQEA GLGLDLDLDR ELEPEMEPKA ETETKTQTEM 901: EPQPETEPEM EPNPKSRPRA HTFPQQRYWP MYHPSMASTQ SQTQTRTWSV ERRRHPMDSY 961: SPEGNSNEDV