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Accession Number: | P40879 |
Protein Name: | Chloride anion exchanger |
Length: | 764 |
Molecular Weight: | 84505.00 |
Species: | Homo sapiens (Human) [9606] |
Number of TMSs: | 12 |
Location1 / Topology2 / Orientation3: | Membrane1 / Multi-pass membrane protein2 |
Substrate | chloride |
Cross database links:
Entrez Gene ID: | 1811 |
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Pfam: | PF01740 PF00916 |
KEGG: | hsa:1811 |
Gene Ontology
GO:0016021
C:integral to membrane
GO:0005624
C:membrane fraction
GO:0005886
C:plasma membrane
GO:0015301
F:anion:anion antiporter activity
GO:0008271
F:secondary active sulfate transmembrane transporter activity
GO:0003700
F:sequence-specific DNA binding transcription factor activity
GO:0003712
F:transcription cofactor activity
GO:0005215
F:transporter activity
GO:0006820
P:anion transport
GO:0007588
P:excretion
GO:0055085
P:transmembrane transport
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References (12)[1] “Identification of a colon mucosa gene that is down-regulated in colon adenomas and adenocarcinomas.” Schweinfest C.W.et.al. 7683425 [2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [3] “Similarities between a soybean nodulin, Neurospora crassa sulphate permease II and a putative human tumour suppressor.” Sandal N.N.et.al. 8140616 [4] “The CFTR associated protein CAP70 interacts with the apical Cl-/HCO3-exchanger DRA in rabbit small intestinal mucosa.” Rossmann H.et.al. 15766278 [5] “ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.” Matsuoka S.et.al. 17525332 [6] “Mutations of the Down-regulated in adenoma (DRA) gene cause congenital chloride diarrhoea.” Hoeglund P.et.al. 8896562 [7] “Genetic background of congenital chloride diarrhea in high-incidence populations: Finland, Poland, and Saudi Arabia and Kuwait.” Hoglund P.et.al. 9718329 [8] “Clustering of private mutations in the congenital chloride diarrhea/down-regulated in adenoma gene.” Hoeglund P.et.al. 9554749 |
External Searches:
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Analyze:
Predict TMSs (Predict number of transmembrane segments) | ||||
FASTA formatted sequence |
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1: MIEPFGNQYI VARPVYSTNA FEENHKKTGR HHKTFLDHLK VCCSCSPQKA KRIVLSLFPI 61: ASWLPAYRLK EWLLSDIVSG ISTGIVAVLQ GLAFALLVDI PPVYGLYASF FPAIIYLFFG 121: TSRHISVGPF PILSMMVGLA VSGAVSKAVP DRNATTLGLP NNSNNSSLLD DERVRVAAAA 181: SVTVLSGIIQ LAFGILRIGF VVIYLSESLI SGFTTAAAVH VLVSQLKFIF QLTVPSHTDP 241: VSIFKVLYSV FSQIEKTNIA DLVTALIVLL VVSIVKEINQ RFKDKLPVPI PIEFIMTVIA 301: AGVSYGCDFK NRFKVAVVGD MNPGFQPPIT PDVETFQNTV GDCFGIAMVA FAVAFSVASV 361: YSLKYDYPLD GNQELIALGL GNIVCGVFRG FAGSTALSRS AVQESTGGKT QIAGLIGAII 421: VLIVVLAIGF LLAPLQKSVL AALALGNLKG MLMQFAEIGR LWRKDKYDCL IWIMTFIFTI 481: VLGLGLGLAA SVAFQLLTIV FRTQFPKCST LANIGRTNIY KNKKDYYDMY EPEGVKIFRC 541: PSPIYFANIG FFRRKLIDAV GFSPLRILRK RNKALRKIRK LQKQGLLQVT PKGFICTVDT 601: IKDSDEELDN NQIEVLDQPI NTTDLPFHID WNDDLPLNIE VPKISLHSLI LDFSAVSFLD 661: VSSVRGLKSI LQEFIRIKVD VYIVGTDDDF IEKLNRYEFF DGEVKSSIFF LTIHDAVLHI 721: LMKKDYSTSK FNPSQEKDGK IDFTINTNGG LRNRVYEVPV ETKF