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| Accession Number: | Q8TE54 |
| Protein Name: | Anion exchange transporter |
| Length: | 656 |
| Molecular Weight: | 72213.00 |
| Species: | [9606] |
| Number of TMSs: | 8 |
| Location1 / Topology2 / Orientation3: | Recycling endosome membrane1 / Multi-pass membrane protein2 |
| Substrate | chloride, bromide, iodide, glucarate(2-), hydrogencarbonate, sulfate, oxalate(2-), nitrate, hydroxide |
Cross database links:
| RefSeq: | NP_439897.1 NP_599028.1 |
|---|---|
| Entrez Gene ID: | 115111 |
| Pfam: | PF01740 PF00916 |
| OMIM: |
608479 gene |
| KEGG: | hsa:115111 hsa:115111 |
Gene Ontology
GO:0016323
C:basolateral plasma membrane
GO:0016021
C:integral to membrane
GO:0055038
C:recycling endosome membrane
GO:0015380
F:anion exchanger activity
GO:0015106
F:bicarbonate transmembrane transporter activity
GO:0005254
F:chloride channel activity
GO:0019531
F:oxalate transmembrane transporter activity
GO:0015116
F:sulfate transmembrane transporter activity
GO:0015701
P:bicarbonate transport
GO:0006821
P:chloride transport
GO:0019532
P:oxalate transport
GO:0008272
P:sulfate transport
GO:0055085
P:transmembrane transport
GO:0005768
C:endosome
GO:0015301
F:anion:anion antiporter activity
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References (14)[1] “Molecular cloning of SLC26A7, a novel member of the SLC26 sulfate/anion transporter family, from high endothelial venules and kidney.” Vincourt J.-B.et.al. 11829495 [2] “Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9.” Lohi H.et.al. 11834742 [3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [4] “Identification of a basolateral Cl-/HCO3- exchanger specific to gastric parietal cells.” Petrovic S.et.al. 12736153 [5] “SLC26A6 and SLC26A7 anion exchangers have a distinct distribution in human kidney.” Kujala M.et.al. 15956810 [6] “Chloride/bicarbonate exchanger SLC26A7 is localized in endosomes in medullary collecting duct cells and is targeted to the basolateral membrane in hypertonicity and potassium depletion.” Xu J.et.al. 16524946 [7] “Expression of ion transport-associated proteins in human efferent and epididymal ducts.” Kujala M.et.al. 17504921 [8] “Molecular cloning of SLC26A7, a novel member of the SLC26 sulfate/anion transporter family, from high endothelial venules and kidney.” Vincourt J.-B.et.al. 11829495 [9] “Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9.” Lohi H.et.al. 11834742 [10] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [11] “Identification of a basolateral Cl-/HCO3- exchanger specific to gastric parietal cells.” Petrovic S.et.al. 12736153 [12] “SLC26A6 and SLC26A7 anion exchangers have a distinct distribution in human kidney.” Kujala M.et.al. 15956810 [13] “Chloride/bicarbonate exchanger SLC26A7 is localized in endosomes in medullary collecting duct cells and is targeted to the basolateral membrane in hypertonicity and potassium depletion.” Xu J.et.al. 16524946 [14] “Expression of ion transport-associated proteins in human efferent and epididymal ducts.” Kujala M.et.al. 17504921
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External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MTGAKRKKKS MLWSKMHTPQ CEDIIQWCRR RLPILDWAPH YNLKENLLPD TVSGIMLAVQ 61: QVTQGLAFAV LSSVHPVFGL YGSLFPAIIY AIFGMGHHVA TGTFALTSLI SANAVERIVP 121: QNMQNLTTQS NTSVLGLSDF EMQRIHVAAA VSFLGGVIQV AMFVLQLGSA TFVVTEPVIS 181: AMTTGAATHV VTSQVKYLLG MKMPYISGPL GFFYIYAYVF ENIKSVRLEA LLLSLLSIVV 241: LVLVKELNEQ FKRKIKVVLP VDLVLIIAAS FACYCTNMEN TYGLEVVGHI PQGIPSPRAP 301: PMNILSAVIT EAFGVALVGY VASLALAQGS AKKFKYSIDD NQEFLAHGLS NIVSSFFFCI 361: PSAAAMGRTA GLYSTGAKTQ VACLISCIFV LIVIYAIGPL LYWLPMCVLA SIIVVGLKGM 421: LIQFRDLKKY WNVDKIDWGI WVSTYVFTIC FAANVGLLFG VVCTIAIVIG RFPRAMTVSI 481: KNMKEMEFKV KTEMDSETLQ QVKIISINNP LVFLNAKKFY TDLMNMIQKE NACNQPLDDI 541: SKCEQNTLLN SLSNGNCNEE ASQSCPNEKC YLILDCSGFT FFDYSGVSML VEVYMDCKGR 601: SVDVLLAHCT ASLIKAMTYY GNLDSEKPIF FESVSAAISH IHSNKNLSKL SDHSEV