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2.A.57.4.1
The parasite plasma membrane equilibrative nucleoside transporter, PfNT1 or PfENT1, of 422 aas and 10 or 11 TMSs. Both L- and D-nucleosides of both purines and pyrimidines are transported; L-nucleosides are transported with low affinity (transports adenosine, inosine and thymidine (KM values=1-2mM) (Downie et al., 2006)). ENT1 is the primary uptake transporter for purines, and transmembrane segments 2, 10 and 11 appear to line the purine permeation pathway (Riegelhaupt et al., 2010, Nishtala et al. 2018).

Accession Number:Q9NIH7
Protein Name:PfNT1 aka NT1 aka ENT1
Length:422
Molecular Weight:47631.00
Species:Plasmodium falciparum [5833]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate L-adenosine, L-inosine, L-thymidine, Nucleosides

Cross database links:

Pfam: PF01733   

Gene Ontology

GO:0016020 C:membrane
GO:0005337 F:nucleoside transmembrane transporter activity
GO:0006810 P:transport

References (2)

[1] “Isolation and functional characterization of the PfNT1 nucleoside transporter gene from Plasmodium falciparum.”  Carter N.S.et.al.   10744765
[2] “Identification of a nucleoside/nucleobase transporter from Plasmodium falciparum, a novel target for anti-malarial chemotherapy.”  Parker M.D.et.al.   10861212

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSTGKESSKA YADIESRGDY KDDGKKGSTL SSKQHFMLSL TFILIGLSSL NVWNTALGLN 
61:	INFKYNTFQI TGLVCSSIVA LFVEIPKIML PFLLGGLSIL CAGFQISHSF FTDTQFDTYC 
121:	LVAFIVIGVV AGLAQTIAFN IGSTMEDNMG GYMSAGIGIS GVFIFVINLL LDQFVSPEKH 
181:	YGVNKAKLLY LYIICELCLI LAIVFCVCNL DLTNKNNKKD EENKENNATL SYMELFKDSY 
241:	KAILTMFLVN WLTLQLFPGV GHKKWQESHN ISDYNVTIIV GMFQVFDFLS RYPPNLTHIK 
301:	IFKNFTFSLN KLLVANSLRL LFIPWFILNA CVDHPFFKNI VQQCVCMAML AFTNGWFNTV 
361:	PFLVFVKELK KAKKKKEIEI ISTFLVIAMF VGLFCGIWTT YIYNLFNIVL PKPDLPPIDV 
421:	TQ