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TCID	Name	Domain	Kingdom/Phylum	Protein(s)
2.A.58.1.1	Renal Na⁺-dependent phosphate transport protein 2 (NPT2). Catalyzes 3Na⁺:1Pi symport (Ghezzi et al., 2009).	Eukaryota	Metazoa, Chordata	NPT2 of Rattus norvegicus (Q60825)
2.A.58.1.2	Na⁺-dependent phosphate transporter, NptA (Lebens et al. 2002).	Bacteria	Pseudomonadota	NptA of Vibrio cholerae
2.A.58.1.3	Renal Na⁺/phosphate electroneutral symporter, NPTIIc, NPT2a or NaPi-IIc; responsible for hypophosphatemic hypercalciuric nephrolithiasis associated with rickets (Stechman et al., 2007). Catalyzes 2Na⁺:1Pi symport (Ghezzi et al., 2009). Interacts functionally with CFTR (Bakouh et al., 2012). Also interacts with PDZ1 but not PDZ2 of NHERF1 (Mamonova et al. 2015).	Eukaryota	Metazoa, Chordata	SLC34A3 of Homo sapiens
2.A.58.1.4	Sodium-dependent phosphate transport protein 2B (Na⁺:phosphate symporter 2b) (NaPi-2B or NaPi2b) (Sodium/phosphate cotransporter 2B) (Na⁺/Pi cotransporter 2B) (NaPi-2b) (Solute carrier family 34 member 2). The membrane potential and cation interactions induce large-scale structural rearrangements of the protein (Patti et al. 2016). It may be involved in actively transporting phosphate into cells as the main phosphate transport protein in the intestinal brush border membrane. It may also play a role in the synthesis of surfactant in lung alveoli, and in the pathogenesis of pulmonary alveolar microlithiasis (PAM), a rare, autosomal recessive lung disorder associated with progressive accumulation of calcium phosphate microliths (Saito et al. 2015). NaPi2b may be a possible target for delivery of cytotoxic agents via antibody-drug conjugate models for some patients with lung adenocarcinoma (Heynemann et al. 2021). SLC34A2 promotes cancer proliferation and cell cycle progression by targeting TMPRSS3 in colorectal cancer (Yang et al. 2022). The genetic variant spectrum of SLC34A2 in pulmonary alveolar microlithiasis has been reviewed (Jönsson et al. 2023).	Eukaryota	Metazoa, Chordata	SLC34A2 of Homo sapiens
2.A.58.1.5	Sodium-dependent phosphate transport protein 2A (Sodium-phosphate transport protein 2A; Na⁺-dependent phosphate cotransporter 2A; NaPiIIa; NaPi-3; NaPi-2a) (Solute carrier family 34 member 1; SLC34A1) of 639 aas and 12 TMSs. Structure-function relationships of the first and fourth predicted extracellular linkers of the type IIa Na⁺/Pi cotransporter have been stidied (Ehnes et al. 2004). It co-transports 3 Na⁺ with 1 divalent phosphate anion. There are 3 Na⁺ binding sites, N1 (binds Na⁺ or Li⁺), N2 and N3, (both of which are Na⁺-specific); residues comprising N1 have been identified (Fenollar-Ferrer et al. 2015). Glucocorticoid-induced acute diuresis in rats is due to reduced renal expression of sodium-dependent cotransporter genes (Zhao et al. 2024). Glucocorticoids, including dexamethasone (Dex) and prednisolone (PSL), acutely induced diuresis. Dex significantly increased the urinary excretion of sodium, potassium, chloride, glucose, and inorganic phosphorus by increasing expression of the Na+-dependent transporter genes (Zhao et al. 2024).	Eukaryota	Metazoa, Chordata	SLC34A1 of Homo sapiens
2.A.58.1.6	Sodium-dependent phosphate transporter, NaPi-IIA. The stoichiometry is probably 3 Na⁺ to 1 phosphate molecules. Orthologous to 2.A.58.1.4. Predicted to have 12 TMSs with both the N- and C-termini intracellular (Radanovic et al. 2006). The K_m for phosphate is 80 μM (Zhifeng et al. 2012).	Eukaryota	Metazoa, Chordata	NaPi-IIB of Sus scrofa
2.A.58.1.7	Sodium:phosphate cotransporter of 621 aas and 10 TMSs, NaPi-IIb (SLC34a2). The amino acid sequence showed 79.0 and 70.9% sequence identity to the Astyanax mexicanus and Pundamilia nyererei orthologues, respectively. The protein had eight predicted TMSs, with the amino and carboxy termini intracellular (Chen et al. 2016). Three isoforms have been evaluated with respect to the effects of diatary inorganic phosphate and vitamin D in several tisseues have been determined (Chen et al. 2017).	Eukaryota	Metazoa, Chordata	NaPi-IIb of Tachysurus fulvidraco (Yellow catfish) (Pimelodus fulvidraco)
2.A.58.1.8	Sodium-dependent phosphate cotransporterSLC34 Na⁺:P_i symporter of 350 aas and 10 TMSs.	Bacteria	Bacteroidota	NptA of Algoriphagus ornithinivorans
2.A.58.1.9	Uncharacterized protein of 370 aas and 9 TMSs	Archaea	Euryarchaeota	UP of Salinarchaeum sp. Harcht-Bsk1
2.A.58.2.1	Inorganic phosphate transporter, YjbB. May be able to catalyze both uptake and efflux (Motomura et al. 2011; Ebert et al. 2013).	Bacteria	Pseudomonadota	YjbB of E. coli (P0AF43)
2.A.58.2.2	8 TMS NaPi co-transporter with a PhoU C-terminal domain	Bacteria	Fusobacteriota	NaPi transporter of Fusobacterium nucleatum
2.A.58.2.3	NaPi cotransporter with 8 TMSs and a C-terminal PhoU domain	Bacteria	Bacillota	NaPi transporter of Natranaeoblius thermophilus
2.A.58.2.4	Na⁺/Pi cotransporter of 616 aas (Ebert et al. 2013).	Bacteria	Pseudomonadota	Phosphate transporter of Dinoroseobacter shibae
2.A.58.2.5	YqeW, putative inorganic phosphate up take transporter of 307 aas and 8 TMSs.	Bacteria	Bacillota	YqeW of Bacillus subtilis
2.A.58.2.6	Putative Na⁺-dependent phosphate symporter of 558 aas and 9 TMSs.	Archaea	Euryarchaeota	PNaS family member of Methanocella arvoryzae
2.A.58.2.7	Na/Pi cotransporter family protein of 535 aas and 8 TMSs.	Archaea	Candidatus Nanohaloarchaeota	Phosphate transporter of Candidatus Nanohaloarchaeota archaeon