2.A.6.5.12
MmpL4a of 959 aas and 12 TMSs. A rough morphotype has a Y842H mutation that causes a deficiency in
glycopeptidolipid production and a gain in the capacity to produce cords
in vitro. In zebrafish, increased virulence of the M. bolletii R variant over the parental S strain
was noted, involving massive production of serpentine cords, abscess formation and rapid larval
death. Tyr842 is conserved in several MmpL proteins (Bernut et al. 2016).
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| Accession Number: | A5A9P9 |
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| Protein Name: | Membrane protein |
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| Length: | 959 |
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| Molecular Weight: | 104113.00 |
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| Species: | Mycobacterium chelonae [1774] |
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| Number of TMSs: | 12 |
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| Substrate |
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1: MSESDGKGQS HRPIMATIIR KGAVFIILGW LAITVLLTVK VPPLEIVERE HSVSLSPPDA
61: PSVKAMTQMG KVFQESNSES VAVIVLEGEN PLGDDAHKYY DAVVRQLKDD PKHVQHIQDF
121: WGDPLTAGAA QSADGKAAYV QLNLTGRFGQ ADANESVEAV QKIVKDTPGL PPGVKTYVTG
181: PAAVVSDMSE SGNRTVILIT LVSVGVIFLM LLLLYRSFIT VIILLFTVGI ELQVARGLVA
241: FLGMHGIVGL TTFVVNLLVS VGIAAGTDYG IFFTGRYQEA RQAGEDRQTA YYTAYRGVAK
301: VVLASGLTIA GAIACLHFTR LPYFKPLGIP GAVGILVAVA VALTLVPACI AAGSRFGLFD
361: PKRQVTTRRW RRLGTAIVRW PGPILAGTVA ISLIGLLTLP GYNPSYTDAK YIPKDIPAVQ
421: GLVAASRHFP ESKMSTPDIL LVEANHDMRN SADLLVLNRL AKAVFAVPGI ANVQSITRPE
481: GTQIEHSSVP FMLSMSNASQ RLSLPFQRAR MDDMLKQADD MGTTIALMQR MFDLMKQMVA
541: TTHRMVSTTH DLQKDMSTLR DHIENFEDFW RPIRNYFYWE KHCFDIPICW SIRSIFDALD
601: GVDQVTDKMQ TLVGDLDELD RLMPQLLEQF PIMIDTMKST RESMLTMHST MSGIFAQMDE
661: STENSTAMGK AFDASKNDDS FYLPPDVLNN KDFKRVMKIF MSPDGKSTRM LISQRGDPAT
721: PEGIARVDPI KTAAEEALKG TPLEHAKISL AGTAAGVSEL VDGSKYDLLI AGVAALCLIF
781: IIMLLMTRSL VAALVIVGTV ALSLGASFGL SVLVWQHICG IQINWVVLAM SVIVLLAVGS
841: DYNLLLVSRM KEELGAGLNT GIIRAMGGTG KVVTAAGLVF AATMGSMIVS DLLTLGQVGT
901: TIGLGLLFDT LIVRAFMTPA IAALLGRWFW WPLQVSPRPV GAVHGWKGPR LVRSVLQRN