2.A.6.6.12
Niemann-Pick C1 protein, NPC1 of 1339 aas and 16 TMSs in a 1 + 3 + 1 +5 + 1 +5 arrangement. Trafficking of EhNPC1 and EhNPC2 during cholesterol uptake and phagocytosis as well as their association with molecules involved in endocytosis clearly suggest that these proteins play a key role in cholesterol uptake (Bolaños et al. 2016).
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| Accession Number: | M3TK92 |
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| Protein Name: | Niemann-Pick C1 protein, putative |
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| Length: | 1339 |
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| Molecular Weight: | 152567.00 |
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| Species: | Entamoeba histolytica HM-1:IMSS-B [885319] |
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| Number of TMSs: | 15 |
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| Substrate |
cholesterol |
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1: MFVFFFLISV VISITPLPGG ERDINNLDQY NNKCRMHNVP GCTAPAINMK SDGTLYLTDA
61: YPAPKNMIEI CISEHPEFDP NVTLGHKTCC DEHSVLDLKE QSTLLDGSFG KCPACYLNQM
121: NLWCGFACDP NSARWTEIDD FKHDNTCNEP DGIDVPSLYY YLHPLYAQQI YDSCKDTELS
181: GGFAVRSLYP TYKEFFQMIS DVNPVMPLHF VYDETGYNGS KYTEMHKCSD MCSCQSCHEM
241: CTEFIEDEPT FKDYPFLDGT LNIITIISIH LFMLFIMVTI TVCGGILSYK TFTQMKKSNP
301: TLLYISYISL GAVTLLGIGF IIMGIIVVGF PMEGVITSMP WGDGNLLGMI LLYIGFGVYV
361: IGYSVYDLYY FVIYTLYNKK ESEDIIDSAK VSILGQEESC EEDPNKVDLT DNFLSKAMSW
421: YTKFLWKFKW IILTVVILCC IVLCVGVFKI VFITDSLGLW VPKNCQTMKD KNYYDEAFGP
481: FFRINQFMLS DKLHPGNQVL TQPLIVQLQQ MIDEIRAIHV EWTDKETGIT KDITMDDMCY
541: KPVFGKGCII TSVTGYWQHD INKIMNTENV TQYIQNCLGN PLATGCADDI GSPVDPHNSL
601: GNYTVGDNND PMKATILQAT FMFNQPNKTA IEWAELWEEK YLEILDRDYS LVKVAYQAQR
661: SVDDEINRET FTDVLTVLCS YMVMFIYISL SLGNSFYHFN YKTVFVKSRI LLGILGIVIV
721: LFSVFTSAGF FSWINVEATL IITEVIPFLV LAIGVDNIFI LTNTIDEQPM YDKDGQYVPV
781: EKRLEHSLMH VGPSMMLASI SESLAFFLGY LTSMPAVQSF SLYAGLAIFI DFILQITVYA
841: VLLCYDVKRQ ESHGLDFIPW LQVHDNSLDE QHDFERGSLI KHLFKYVATF LSYYPVKIIG
901: LFFFIAFFIF SLNYVPKTML GLPQETALPQ DSYIQDYFVA LTYLEIGPPV YIVVRDGATY
961: LNETTQSALC ASDNFGCDAL SIPNYYDAAR TIDGTTFDWI DDYFSWAAQK DCCRLDKDGN
1021: ICPYDMPNYT ECTPCFTNFT DKKRPVPEDF YKYINRFLTA SINETLCSVN GQAYYPDVVW
1081: NHINGTKETD YSYVNVSRLR LYHTVLVTQD DFIDAMVQAY NISDYMNSIF DVKTFPYAYH
1141: YVYFQQYFNI VDLCVMDVCL ALAAVFIVVM LLMFDPIVAI MIVLCVLMCV IDLIGIMYLW
1201: GVELNAVSCV NLVMSIGITI EFCVHIAHAF LSSPKKTLND KMKDAVMNMG NNVFVGITLT
1261: KFLGVIVLSL SSGLIFVIYY FRMYFMMLIF GASHGLFFLP ILLSLIPSVS LSHITDPFKK
1321: MFGRCNKKKS TKGEYQNFE