2.A.6.6.15
Niemann-Pick type C1 type 1a isoform A of 1287 aas and 14 TMSs. One TMS is N-terminal, one is at position 280 aa, and this is followed by another TMS at position 360 followed by the usual 5 + 1 + 5 TMs arrangement, where each of the 5 TMS units have these TMSs in a 3 + 2 TMS arrangement with a strong peak of amphipathicity between the third and the fourth TMSs. The ortholog regulates cholesterol transport and metamorphosis in the silkworm, Bombyx mori (Ke et al. 2020).
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| Accession Number: | Q9VL24 |
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| Protein Name: | Niemann-Pick type C-1a, isoform A |
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| Length: | 1287 |
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| Molecular Weight: | 143292.00 |
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| Species: | Drosophila melanogaster (Fruit fly) [7227] |
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| Number of TMSs: | 14 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
cholesterol |
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1: MSPRSPLRIS PFGVHILIAA VLFTLIQSSK QDCVWYGVCN TNDFSHSQNC PYNGTAKEMA
61: TDGLELLKKR CGFLLENSEN KFCCDKNQVE LLNKNVELAG NILDRCPSCM ENLVRHICQF
121: TCSPKQAEFM HVVATQKNKK GDEYISSVDL HISTEYINKT YKSCSQVSVP QTGQLAFDLM
181: CGAYSASRCN PTKWFNFMGD ATNPYVPFQI TYIQHEPKSN SNNFTPLNVT TVPCNQAVSS
241: KLPACSCSDC DLSCPQGPPE PPRPEPFKIV GLDAYFVIMA AVFLVGVLVF LMGSFLFTQG
301: SSMDDNFQVD GNDVSDEMPY SENDSYFEKL GAHTETFLET FFTKWGTYFA SNPGLTLIAG
361: ASLVVILGYG INFIEITTDP VKLWASPNSK SRLEREFFDT KFSPFYRLEQ IIIKAVNLPQ
421: IVHNTSNGPY TFGPVFDREF LTKVLDLQEG IKEINANGTQ LKDICYAPLS DDGSEIDVSQ
481: CVVQSIWGYF GDDRERLDDH DEDNGFNVTY LDALYDCISN PYLCLAPYGG PVDPAIALGG
541: FLPPGDQLTG STKFELANAI ILTFLVKNHH NKTDLENALT WEKKFVEFMT NYTKNNMSQY
601: MDIAFTSERS IEDELNRESQ SDVLTILVSY LIMFMYIAIS LGHVKEFKRV FIDSKITLGI
661: GGVIIVLASV VSSVGVFGYI GLPATLIIVE VIPFLVLAVG VDNIFILVQT HQRDQRKPNE
721: TLEQQVGRIL GKVGPSMLLT SLSESFCFFL GGLSDMPAVR AFALYAGVAL IIDFLLQITC
781: FVSLFTLDTK RREENRMDIC CFIKGKKPDS ITSNEGLLYK FFSSVYVPFL MKKIVRASVM
841: VIFFAWLCFS IAIAPRIDIG LDQELAMPQD SFVLHYFQSL NENLNIGPPV YFVLKGDLAY
901: TNSSDQNLVC AGQYCNDDSV LTQIYLASRH SNQTYIARPA SSWIDDYFDW AAAASSCCKY
961: RKDSGDFCPH QDTSCLRCNI TKNSLLRPEE KEFVKYLPFF LKDNPDDTCA KAGHAAYGGA
1021: VRYSNSHERL NIEASYFMAY HTILKSSADY FLALESARKI SANITQMLQG RLMSNGVPMA
1081: SALTVEVFPY SVFYVFYEQY LTMWSDTLQS MGISVLSIFV VTFVLMGFDV HSALVVVITI
1141: TMIVVNLGGL MYYWNISLNA VSLVNLVMAV GISVEFCSHL VHSFATSKSV SQIDRAADSL
1201: SKMGSSIFSG ITLTKFAGIL VLAFAKSQIF QVFYFRMYLG IVVIGAAHGL IFLPVLLSYI
1261: GAPVSNARLR YHSQAAAEHE TALAGIL