| |
|---|---|
| Accession Number: | Q2G140 |
| Protein Name: | Multidrug export protein mepA |
| Length: | 451 |
| Molecular Weight: | 48776.00 |
| Species: | Staphylococcus aureus (strain NCTC 8325) [93061] |
| Number of TMSs: | 12 |
| Location1 / Topology2 / Orientation3: | Cell membrane1 / Multi-pass membrane protein2 |
| Substrate | fluoroquinolone antibiotic, tigecycline |
Cross database links:
| RefSeq: | YP_498905.1 |
|---|---|
| Entrez Gene ID: | 3919542 |
| Pfam: | PF01554 |
| BioCyc: | SAUR93061:SAOUHSC_00315-MONOMER |
| KEGG: | sao:SAOUHSC_003 |
Gene Ontology
GO:0016021
C:integral to membrane
GO:0005886
C:plasma membrane
GO:0015297
F:antiporter activity
GO:0015238
F:drug transmembrane transporter activity
GO:0006855
P:drug transmembrane transport
GO:0046677
P:response to antibiotic
| |
References (3)[1] “Multidrug resistance in Staphylococcus aureus due to overexpression of a novel multidrug and toxin extrusion (MATE) transport protein.” Kaatz G.W.et.al. 15855507 | |
External Searches:
|
Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
|
|||
1: MKDEQLYYFE KSPVFKAMMH FSLPMMIGTL LSVIYGILNI YFIGFLEDSH MISAISLTLP 61: VFAILMGLGN LFGVGAGTYI SRLLGAKDYS KSKFVSSFSI YGGIALGLIV ILVTLPFSDQ 121: IAAILGARGE TLALTSNYLK VMFLSAPFVI LFFILEQFAR AIGAPMVSMI GMLASVGLNI 181: ILDPILIFGF DLNVVGAALG TAISNVAAAL FFIIYFMKNS DVVSVNIKLA KPNKEMLSEI 241: FKIGIPAFLM SILMGFTGLV LNLFLAHYGN FAIASYGISF RLVQFPELII MGLCEGVVPL 301: IAYNFMANKG RMKDVIKAVI MSIGVIFVVC MSAVFTIGHH MVGLFTTDQA IVEMATFILK 361: VTMASLLLNG IGFLFTGMLQ ATGQGRGATI MAILQGAIII PVLFIMNALF GLTGVIWSLL 421: IAESLCALAA MLIVYLLRDR LTVDTSELIE G