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2.A.66.1.14
Human MATE1 electroneutral organocation:H antiporter (transports tetraethylammonium, TEA, and cimetidine as well as cisplatin and oxaliplatin) (Yonezawa et al., 2006). MATE1 also exports chloroquine across the luminal membrane (Müller et al., 2011). It has an established 13 TMS topology with the "extra" TMS in an extracellular C-terminal region that is not essential for function (Zhang et al., 2012).  Also exports 1-methyl-4-phenylpyridinium (MPP), N-methylnicotinamide (NMN), metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, cimetidine, ganciclovir and the zwitterionic cephalosporin, cephalexin and cephradin (Nigam 2015). Seems to also play a role in the uptake of oxaliplatin (a platinum anticancer agent). Able to transport paraquat (PQ or N,N-dimethyl-4-4'-bipiridinium); a widely used herbicid. Responsible for the secretion of cationic drugs across the brush border membranes (Tanihara et al. 2007).  Nucleobases and nucleoside-derived anticancer and antiviral agents (flucytosine, cytarabine, gemcitabine, capecitabine) are novel drug substrates of this MATE1 transporter (Nies et al. 2023).

Accession Number:Q96FL8
Protein Name:MATE-1
Length:570
Molecular Weight:61922.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate tetraethylammonium, creatinine, cephalosporin, ganciclovir, guanidine, gemcitabine, topotecan, cisplatin, N-methyl-4-phenylpyridinium, paraquat, chloroquine, flucytosine, cimetidine, N-methylnicotinamide, procainamide, metformin, oxaliplatin, estrone 3-sulfate, acyclovir

Cross database links:

RefSeq: NP_060712.2   
Entrez Gene ID: 55244   
Pfam: PF01554   
OMIM: 609832  gene
KEGG: hsa:55244    hsa:55244   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015297 F:antiporter activity
GO:0015238 F:drug transmembrane transporter activity
GO:0006855 P:drug transmembrane transport
GO:0005624 C:membrane fraction
GO:0005451 F:monovalent cation:hydrogen antiporter activity
GO:0015695 P:organic cation transport
GO:0055085 P:transmembrane transport

References (16)

[1] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[3] “A human transporter protein that mediates the final excretion step for toxic organic cations.”  Otsuka M.et.al.   16330770
[4] “Wide variety of locations for rodent MATE1, a transporter protein that mediates the final excretion step for toxic organic cations.”  Hiasa M.et.al.   16641166
[5] “The MATE proteins as fundamental transporters of metabolic and xenobiotic organic cations.”  Omote H.et.al.   16996621
[6] “Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters.”  Tanihara Y.et.al.   17509534
[7] “Differential contribution of organic cation transporters, OCT2 and MATE1, in platinum agent-induced nephrotoxicity.”  Yokoo S.et.al.   17582384
[8] “Transport of paraquat by human organic cation transporters and multidrug and toxic compound extrusion family.”  Chen Y.et.al.   17495125
[9] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[10] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[11] “A human transporter protein that mediates the final excretion step for toxic organic cations.”  Otsuka M.et.al.   16330770
[12] “Wide variety of locations for rodent MATE1, a transporter protein that mediates the final excretion step for toxic organic cations.”  Hiasa M.et.al.   16641166
[13] “The MATE proteins as fundamental transporters of metabolic and xenobiotic organic cations.”  Omote H.et.al.   16996621
[14] “Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters.”  Tanihara Y.et.al.   17509534
[15] “Differential contribution of organic cation transporters, OCT2 and MATE1, in platinum agent-induced nephrotoxicity.”  Yokoo S.et.al.   17582384
[16] “Transport of paraquat by human organic cation transporters and multidrug and toxic compound extrusion family.”  Chen Y.et.al.   17495125

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MEAPEEPAPV RGGPEATLEV RGSRCLRLSA FREELRALLV LAGPAFLVQL MVFLISFISS 
61:	VFCGHLGKLE LDAVTLAIAV INVTGVSVGF GLSSACDTLI SQTYGSQNLK HVGVILQRSA 
121:	LVLLLCCFPC WALFLNTQHI LLLFRQDPDV SRLTQTYVTI FIPALPATFL YMLQVKYLLN 
181:	QGIVLPQIVT GVAANLVNAL ANYLFLHQLH LGVIGSALAN LISQYTLALL LFLYILGKKL 
241:	HQATWGGWSL ECLQDWASFL RLAIPSMLML CMEWWAYEVG SFLSGILGMV ELGAQSIVYE 
301:	LAIIVYMVPA GFSVAASVRV GNALGAGDME QARKSSTVSL LITVLFAVAF SVLLLSCKDH 
361:	VGYIFTTDRD IINLVAQVVP IYAVSHLFEA LACTSGGVLR GSGNQKVGAI VNTIGYYVVG 
421:	LPIGIALMFA TTLGVMGLWS GIIICTVFQA VCFLGFIIQL NWKKACQQAQ VHANLKVNNV 
481:	PRSGNSALPQ DPLHPGCPEN LEGILTNDVG KTGEPQSDQQ MRQEEPLPEH PQDGAKLSRK 
541:	QLVLRRGLLL LGVFLILLVG ILVRFYVRIQ