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| Accession Number: | Q5I0E9 |
| Protein Name: | MATE-1 |
| Length: | 566 |
| Molecular Weight: | 61440.00 |
| Species: | Rattus norvegicus (Rat) [10116] |
| Number of TMSs: | 13 |
| Location1 / Topology2 / Orientation3: | Cell membrane1 / Multi-pass membrane protein2 |
| Substrate | hydron, quinidine, imipramine, N-methyl-4-phenylpyridinium, triethylamine, cimetidine, amiloride |
Cross database links:
| RefSeq: | NP_001009645.1 NP_001014140.1 |
|---|---|
| Entrez Gene ID: | 293502 360539 |
| Pfam: | PF01554 |
| KEGG: | rno:360539 |
Gene Ontology
GO:0016021
C:integral to membrane
GO:0005624
C:membrane fraction
GO:0005886
C:plasma membrane
GO:0005451
F:monovalent cation:hydrogen antiporter activity
GO:0015239
?:?
GO:0006855
P:drug transmembrane transport
GO:0015695
P:organic cation transport
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References (8)[1] “Molecular identification and functional characterization of rat multidrug and toxin extrusion type transporter 1 as an organic cation/H+ antiporter in the kidney.” Ohta K.Y.et.al. 16928787 [2] “Molecular cloning, functional characterization and tissue distribution of rat H+/organic cation antiporter MATE1.” Terada T.et.al. 16850272 [3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [4] “Oppositely directed H+ gradient functions as a driving force of rat H+/organic cation antiporter MATE1.” Tsuda M.et.al. 17047166 [5] “Differential contribution of organic cation transporters, OCT2 and MATE1, in platinum agent-induced nephrotoxicity.” Yokoo S.et.al. 17582384 [6] “Pharmacokinetic significance of luminal multidrug and toxin extrusion 1 in chronic renal failure rats.” Nishihara K.et.al. 17296166 [7] “Identification of essential histidine and cysteine residues of the H+/organic cation antiporter multidrug and toxin extrusion (MATE).” Asaka J.et.al. 17327464 [8] “Polyspecific organic cation transporters: structure, function, physiological roles, and biopharmaceutical implications.” Koepsell H.et.al. 17473959
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External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MEVLEEPAPG PGGADAAERR GLRRLLLSGF QEELRALLVL AGPAFLAQLM MFLISFISSV 61: FCGHLGKLEL DAVTLAIAVI NVTGISVGHG LSSACDTLIS QTYGSQNLKH VGVILQRGTL 121: ILLLCCFPCW ALFINTEQIL LLFRQDPDVS RLTQTYVMVF IPALPAAFLY TLQVKYLLNQ 181: GIVLPQVITG IAANLVNALA NYLFLHQLHL GVMGSALANT ISQFALAIFL FLYILWRKLH 241: HATWGGWSWE CLQDWASFLQ LAIPSMLMLC IEWWAYEVGS FLSGILGMVE LGAQSITYEL 301: AIIVYMIPAG FSVAANVRVG NALGAGNIDQ AKKSSAISLI VTELFAVTFC VLLLGCKDLV 361: GYIFTTDWDI VALVAQVVPI YAVSHLFEAL ACTCGGVLRG TGNQKVGAIV NAIGYYVIGL 421: PIGISLMFVA KLGVIGLWSG IIICSVCQTS CFLVFIARLN WKLACQQAQV HANLKVNVAL 481: NSAVSQEPAH PVGPESHGEI MMTDLEKKDE IQLDQQMNQQ QALPVHPKDS NKLSGKQLAL 541: RRGLLFLGVV LVLVGGILVR VYIRTE