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2.A.66.1.16 Electroneutral organic cation:H⁺ antiporter MATE2 (Hiasa et al., 2007). 50% identical to MATE1; 2.A.66.1.15. OCT3 and MATE2 genetic polymorphisms can give rise to poor responses to metformin in type 2 diabetes mellitus (Naem et al. 2024).
Accession Number:	Q3V050
Protein Name:	Slc47a2 aka Mate2
Length:	573
Molecular Weight:	61789.00
Species:	Mus musculus GN=Slc47a2 PE=1 SV=1 [10090]
Number of TMSs:	13
Location¹ / Topology² / Orientation³:	Membrane¹ / Multi-pass membrane protein²
Substrate	organic cation, hydron

RefSeq:	NP_001028714.1
Entrez Gene ID:	380701
Pfam:	PF01554
KEGG:	mmu:380701
Gene Ontology GO:0016021 C:integral to membrane GO:0015297 F:antiporter activity GO:0015238 F:drug transmembrane transporter activity GO:0006855 P:drug transmembrane transport
References (4) [1] “Functional characterization of testis-specific rodent multidrug and toxic compound extrusion 2, a class III MATE-type polyspecific H+/organic cation exporter.” Hiasa M.et.al. 17715386 [2] “The transcriptional landscape of the mammalian genome.” Carninci P.et.al. 16141072 [3] “Lineage-specific biology revealed by a finished genome assembly of the mouse.” Church D.M.et.al. 19468303 [4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MEPAEDSLGA TIQPPELVRV PRGRSLRILL GLRGALSPDV RREAAALVAL AGPVFLAQLM 
61:	IFLISIVSSI FCGHLGKVEL DAVTLAVSVV NVTGISVGTG LASACDTLMS QSFGGKNLKR 
121:	VGVILQRGIL ILLLCCFPCW AIFLNTERLL LLLRQDPDVA RLAQVYVMIC IPALPAAFLF 
181:	QLQTRYLQSQ GIIMPQVIVG IAANVVNVGM NAFLLYALDL GVVGSAWANT TSQFFLSALL 
241:	FLYVWWKRIH IHTWGGWTRE CFQEWSSYTR LAIPSMFMVC IEWWTFEIGT FLAGLVNVTE 
301:	LGAQAVIYEL ASVAYMVPFG FGVAASVRVG NALGAGNADQ ARCSCTTVLL CAGVCALLVG 
361:	ILLAALKDVV AYIFTNDKDI ISLVSQVMPI FAPFHLFDAL AGTCGGVLRG TGKQKIGAVL 
421:	NTIGYYGFGF PIGVSLMFAA KLGIIGLWAG LIVCVSFQAF SYLIYILRTN WSRVAEQAQV 
481:	RAGLKSTKEL IPTPADLPIL EREVMDGVIL PDIIRPESQT GQLVVEENSQ CAVPTVGEVL 
541:	TGRQLVFYRG MALTVSVAVL IAGIVVRVFN DRG

2.A.66.1.16
Electroneutral organic cation:H⁺ antiporter MATE2 (Hiasa et al., 2007). 50% identical to MATE1; 2.A.66.1.15. OCT3 and MATE2 genetic polymorphisms can give rise to poor responses to metformin in type 2 diabetes mellitus (Naem et al. 2024).

Cross database links:

Gene Ontology

References (4)

External Searches:

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2.A.66.1.16Electroneutral organic cation:H+ antiporter MATE2 (Hiasa et al., 2007). 50% identical to MATE1; 2.A.66.1.15. OCT3 and MATE2 genetic polymorphisms can give rise to poor responses to metformin in type 2 diabetes mellitus (Naem et al. 2024).

Cross database links:

Gene Ontology

References (4)

External Searches:

Analyze:

2.A.66.1.16
Electroneutral organic cation:H⁺ antiporter MATE2 (Hiasa et al., 2007). 50% identical to MATE1; 2.A.66.1.15. OCT3 and MATE2 genetic polymorphisms can give rise to poor responses to metformin in type 2 diabetes mellitus (Naem et al. 2024).