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|---|---|
| Accession Number: | Q86VL8 |
| Protein Name: | Multidrug and toxin extrusion protein 2 |
| Length: | 602 |
| Molecular Weight: | 65085.00 |
| Species: | homo sapiens (Human) [9606] |
| Number of TMSs: | 13 |
| Location1 / Topology2 / Orientation3: | Cell membrane1 / Multi-pass membrane protein2 |
| Substrate | hydron, adefovir, cimetidine, metformin, drug, acyclovir |
Cross database links:
| RefSeq: | NP_001093116.1 NP_690872.2 |
|---|---|
| Entrez Gene ID: | 146802 |
| Pfam: | PF01554 |
| OMIM: |
609833 gene |
| KEGG: | hsa:146802 hsa:146802 hsa:146802 hsa:146802 |
Gene Ontology
GO:0016021
C:integral to membrane
GO:0005886
C:plasma membrane
GO:0015297
F:antiporter activity
GO:0015238
F:drug transmembrane transporter activity
GO:0006855
P:drug transmembrane transport
GO:0055085
P:transmembrane transport
| |
References (24)[1] “Identification and functional characterization of a new human kidney-specific H+/organic cation antiporter, kidney-specific multidrug and toxin extrusion 2.” Masuda S.et.al. 16807400 [2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [3] “The full-ORF clone resource of the German cDNA consortium.” Bechtel S.et.al. 17974005 [4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [5] “The MATE proteins as fundamental transporters of metabolic and xenobiotic organic cations.” Omote H.et.al. 16996621 [6] “Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters.” Tanihara Y.et.al. 17509534 [7] “Identification and functional characterization of a new human kidney-specific H+/organic cation antiporter, kidney-specific multidrug and toxin extrusion 2.” Masuda S.et.al. 16807400 [8] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [9] “The full-ORF clone resource of the German cDNA consortium.” Bechtel S.et.al. 17974005 [10] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [11] “The MATE proteins as fundamental transporters of metabolic and xenobiotic organic cations.” Omote H.et.al. 16996621 [12] “Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters.” Tanihara Y.et.al. 17509534 [13] “Identification and functional characterization of a new human kidney-specific H+/organic cation antiporter, kidney-specific multidrug and toxin extrusion 2.” Masuda S.et.al. 16807400 [14] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [15] “The full-ORF clone resource of the German cDNA consortium.” Bechtel S.et.al. 17974005 [16] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [17] “The MATE proteins as fundamental transporters of metabolic and xenobiotic organic cations.” Omote H.et.al. 16996621 [18] “Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters.” Tanihara Y.et.al. 17509534 [19] “Identification and functional characterization of a new human kidney-specific H+/organic cation antiporter, kidney-specific multidrug and toxin extrusion 2.” Masuda S.et.al. 16807400 [20] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 | |
External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MDSLQDTVAL DHGGCCPALS RLVPRGFGTE MWTLFALSGP LFLFQVLTFM IYIVSTVFCG 61: HLGKVELASV TLAVAFVNVC GVSVGVGLSS ACDTLMSQSF GSPNKKHVGV ILQRGALVLL 121: LCCLPCWALF LNTQHILLLF RQDPDVSRLT QDYVMIFIPG LPVIFLYNLL AKYLQNQGWL 181: KGQEEESPFQ TPGLSILHPS HSHLSRASFH LFQKITWPQV LSGVVGNCVN GVANYALVSV 241: LNLGVRGSAY ANIISQFAQT VFLLLYIVLK KLHLETWAGW SSQCLQDWGP FFSLAVPSML 301: MICVEWWAYE IGSFLMGLLS VVDLSAQAVI YEVATVTYMI PLGLSIGVCV RVGMALGAAD 361: TVQAKRSAVS GVLSIVGISL VLGTLISILK NQLGHIFTND EDVIALVSQV LPVYSVFHVF 421: EAICCVYGGV LRGTGKQAFG AAVNAITYYI IGLPLGILLT FVVRMRIMGL WLGMLACVFL 481: ATAAFVAYTA RLDWKLAAEE AKKHSGRQQQ QRAESTATRP GPEKAVLSSV ATGSSPGITL 541: TTYSRSECHV DFFRTPEEAH ALSAPTSRLS VKQLVIRRGA ALGAASATLM VGLTVRILAT 601: RH