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2.A.66.1.21 H⁺-coupled multidrug efflux pump, AbeM (most like 2.A.66.1.2, NorM of Vibrio cholerae) (Su et al., 2005). Exports norfloxacin, ciprofloxacin, DAPI, acriflavin, Hoechst 33342, daunorubicin, doxorubicin, and ethidium (Su et al., 2005) as well as carbapenem (AlQumaizi et al. 2022).
Accession Number:	Q5FAM9
Protein Name:	Multidrug efflux pump AbeM
Length:	448
Molecular Weight:	48784.00
Species:	acinetobacter baumannii [470]
Number of TMSs:	12
Location¹ / Topology² / Orientation³:	Cell membrane¹ / Multi-pass membrane protein²
Substrate	hydron, 2'-(4-ethoxyphenyl)-5-(4-methylpiperazin-1-yl)-2,5'-bibenzimidazole, ciprofloxacin, norfloxacin, doxorubicin, daunorubicin, nifedipine, ethidium

Pfam:	PF01554
Gene Ontology GO:0016021 C:integral to membrane GO:0015297 F:antiporter activity GO:0015238 F:drug transmembrane transporter activity GO:0006855 P:drug transmembrane transport
References (1) [1] “AbeM, an H+-coupled Acinetobacter baumannii multidrug efflux pump belonging to the MATE family of transporters.” Su X.Z.et.al. 16189122

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MSNVTSFRSE LKQLFHLMLP ILITQFAQAG FGLIDTIMAG HLSAADLAAI AVGVGLWIPV 
61:	MLLFSGIMIA TTPLVAEAKG ARNTEQIPVI VRQSLWVAVI LGVLAMLILQ LMPFFLHVFG 
121:	VPESLQPKAS LFLHAIGLGM PAVTMYAALR GYSEALGHPR PVTVISLLAL VVLIPLNMIF 
181:	MYGLGPIPAL GSAGCGFATS ILQWLMLITL AGYIYKASAY RNTSIFSRFD KISLTWVKRI 
241:	LQLGLPIGLA VFFEVSIFST GALVLSPLGE VFIAAHQVAI SVTSVLFMIP LSLAIALTIR 
301:	VGTYYGEKNW ASMYQVQKIG LSTAVFFALL TMSFIALGRE QIVSVYTQDI NVVPVAMYLL 
361:	WFAMAYQLMD ALQVSAAGCL RGMQDTQAPM WITLMAYWVI AFPIGLYLAR YTDWGVAGVW 
421:	LGLIIGLSIA CVLLLSRLYL NTKRLSQT

2.A.66.1.21
H⁺-coupled multidrug efflux pump, AbeM (most like 2.A.66.1.2, NorM of Vibrio cholerae) (Su et al., 2005). Exports norfloxacin, ciprofloxacin, DAPI, acriflavin, Hoechst 33342, daunorubicin, doxorubicin, and ethidium (Su et al., 2005) as well as carbapenem (AlQumaizi et al. 2022).

Cross database links:

Gene Ontology

References (1)

External Searches:

Analyze:

2.A.66.1.21H+-coupled multidrug efflux pump, AbeM (most like 2.A.66.1.2, NorM of Vibrio cholerae) (Su et al., 2005). Exports norfloxacin, ciprofloxacin, DAPI, acriflavin, Hoechst 33342, daunorubicin, doxorubicin, and ethidium (Su et al., 2005) as well as carbapenem (AlQumaizi et al. 2022).

Cross database links:

Gene Ontology

References (1)

External Searches:

Analyze:

2.A.66.1.21
H⁺-coupled multidrug efflux pump, AbeM (most like 2.A.66.1.2, NorM of Vibrio cholerae) (Su et al., 2005). Exports norfloxacin, ciprofloxacin, DAPI, acriflavin, Hoechst 33342, daunorubicin, doxorubicin, and ethidium (Su et al., 2005) as well as carbapenem (AlQumaizi et al. 2022).