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|---|---|
| Accession Number: | Q9SFB0 |
| Protein Name: | MATE efflux family protein FRD3 |
| Length: | 526 |
| Molecular Weight: | 55946.00 |
| Species: | Arabidopsis thaliana (Mouse-ear cress) [3702] |
| Number of TMSs: | 12 |
| Location1 / Topology2 / Orientation3: | Cell membrane1 / Multi-pass membrane protein2 |
| Substrate | citrate salt |
Cross database links:
| Entrez Gene ID: | 819995 |
|---|---|
| Pfam: | PF01554 |
| KEGG: | ath:AT3G08040 |
Gene Ontology
GO:0016021
C:integral to membrane
GO:0005886
C:plasma membrane
GO:0015297
F:antiporter activity
GO:0015137
F:citrate transmembrane transporter activity
GO:0015238
F:drug transmembrane transporter activity
GO:0005216
F:ion channel activity
GO:0006879
P:cellular iron ion homeostasis
GO:0071369
P:cellular response to ethylene stimulus
GO:0071281
P:cellular response to iron ion
GO:0071732
P:cellular response to nitric oxide
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References (7)[1] “FRD3, a member of the multidrug and toxin efflux family, controls iron deficiency responses in Arabidopsis.” Rogers E.E.et.al. 12172022 [2] “Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.” Salanoubat M.et.al. 11130713 [3] “Empirical analysis of transcriptional activity in the Arabidopsis genome.” Yamada K.et.al. 14593172 [4] “Functional cloning and characterization of a plant efflux carrier for multidrug and heavy metal detoxification.” Li L.et.al. 11739388 [5] “FRD3 controls iron localization in Arabidopsis.” Green L.S.et.al. 15310833 [6] “The FRD3-mediated efflux of citrate into the root vasculature is necessary for efficient iron translocation.” Durrett T.P.et.al. 17351051 [7] “Aluminum-activated citrate and malate transporters from the MATE and ALMT families function independently to confer Arabidopsis aluminum tolerance.” Liu J.et.al. 18826429
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External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MTETGDDLAT VKKPIPFLVI FKDLRHVFSR DTTGREILGI AFPAALALAA DPIASLIDTA 61: FVGRLGAVQL AAVGVSIAIF NQASRITIFP LVSLTTSFVA EEDTMEKMKE EANKANLVHA 121: ETILVQDSLE KGISSPTSND TNQPQQPPAP DTKSNSGNKS NKKEKRTIRT ASTAMILGLI 181: LGLVQAIFLI FSSKLLLGVM GVKPNSPMLS PAHKYLSIRA LGAPALLLSL AMQGIFRGFK 241: DTKTPLFATV VADVINIVLD PIFIFVLRLG IIGAAIAHVI SQYFMTLILF VFLAKKVNLI 301: PPNFGDLQFG RFLKNGLLLL ARTIAVTFCQ TLAAAMAARL GTTPMAAFQI CLQVWLTSSL 361: LNDGLAVAGQ AILACSFAEK DYNKVTAVAS RVLQMGFVLG LGLSVFVGLG LYFGAGVFSK 421: DPAVIHLMAI GIPFIAATQP INSLAFVLDG VNFGASDFAY TAYSMVGVAA ISIAAVIYMA 481: KTNGFIGIWI ALTIYMALRA ITGIARMATG TGPWRFLRGR SSSSSS