2.A.66.1.32
Multidrug:proton antiporter of the DinF subfamily. The structure has been solved to 3.2 Å resolution with and without the substrate, Rhodamine 6 G. The 12 TMSs show asymmetry with a membrane-embedded substrate-binding chamber. Direct competition between the H+ and the substrate during transport was suggested (Lu et al. 2013). However, the opposite was suggested for a sodium antiporter (see TC# 2.A.66.1.10).
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| Accession Number: | Q9KAX3 |
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| Protein Name: | BH2163 protein |
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| Length: | 464 |
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| Molecular Weight: | 50634.00 |
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| Species: | Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125) [272558] |
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| Number of TMSs: | 12 |
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| Substrate |
hydron, drug |
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1: MEQKQQSERL GTEAIPKLLR SLSIPAMIGM FVMALYNVVD TIFISYAVGI EGVAGVTIAF
61: PIMMIMMSMA GALGIGGASV ISRRLGERRG EEANQVFGNI LTVILVLSVI GFISAFTLLG
121: PALQLFGATS VTQGYATDYL FPILLGSIFF FFAFAANNII RSEGNATFAM VTMIVPAVLN
181: ILLDVLFIFG LNMGVLGASI ATVIAQASVT GLVLRYFLTG KSTLSLHWSD LRMKGSVIKE
241: VCLVGLPAFV QQSSASLMMI AINSMLLRFG SDFYVGVFGL VQRIMMFVMM PMMGIMQAMQ
301: PIVGYNYGAK QYSRLRETVM LGFKVATIFS IGIFALLMLF PEALLRVFTA DREVIQAGVS
361: AMHILFCVTF LIGAQIVAGG LYQSLGKPKQ ALILSLSRQI IFLIPLVLIL PHIFGLSGVW
421: WAFPIADVLS FILTVVLLYR DRNVFFLKTK EERELDLVKT ASST