2.A.66.1.37
Multidrug resistance protein, CdeA of 441 aas. Exports ethidium bromide, fluoroquinolone and acriflavin but had no effect on susceptibility to the following antibiotics: norfloxacin, ciprofloxacin,
gentamicin, erythromycin, tetracyclin, and chloramphenicol (Dridi et al. 2004). May be a Na+ antiporter.
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| Accession Number: | Q7WZ38 |
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| Protein Name: | EA protein |
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| Length: | 441 |
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| Molecular Weight: | 48855.00 |
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| Species: | Peptoclostridium difficile [1496] |
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| Number of TMSs: | 12 |
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| Substrate |
sodium(1+), fluoroquinolone antibiotic, 3,6-diamino-10-methylacridinium chloride, ethidium bromide |
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1: MENLFTRKFT TFEFLKFVSP AIISMIFISL YTIIDGIFVS TLVGSDALAS INIVLPIINL
61: VCGFGIMMAT GGGAIVSIRM GENRQDEANS TFSFIVLFSL IVGILFTVIS YFFIKEISIL
121: LGATDKLLPY CITYGKVMIL CTPFYILKFI FEYFARTDGN SKFSLFLSVI GGVTNIILDY
181: VFIKYFGMGL LGAAVATAIG IILTCVLGII YFLSNKSTLK LRKPKTDFRL IRDTMINGSS
241: EMVTELSTGI TTFLFNVVAL KLAGENGLAA LTIVLYAHFL MTSVYLGFAA GVSPLISYNF
301: GAENSDKLKE TFKHSLKFIF ISSLLVFIIA LVFAPFIVRV FVNPDNTVFK LALQGLKIFA
361: FAFLFVGINI FASGFFTAFH NGKISAIISF SRAFVFIIIG IIILPPMLNM TGLWLTVPFA
421: EVITIFISIL FIKKYKGRYK Y