2.A.66.1.51
Multidrug resistance efflux pump, Detoxification 48, DTX48. Functions as a multidrug and toxin extrusion transporter. Contributes to iron homeostasis during stress responses and senescence (Seo et al. 2012). Overexpression of DTX48 alters shoot developmental programs leading to a loss of apical dominance phenotype (Wang et al. 2015).
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| Accession Number: | Q9SLV0 |
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| Protein Name: | Protein DETOXIFICATION 48 |
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| Length: | 532 |
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| Molecular Weight: | 57847.00 |
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| Species: | Arabidopsis thaliana (Mouse-ear cress) [3702] |
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| Number of TMSs: | 12 |
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| Location1 / Topology2 / Orientation3: |
Golgi apparatus membrane1 / Multi-pass membrane protein2 |
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| Substrate |
drug |
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1: MCNSKPSSAS SSLLSCKDKT HISKLETCDT DNPHYSEFRD TDSLDLKRWP SFLEGLEEVK
61: AIGKISGPTA MTGLLMYSRA MISMLFLGYL GELELAGGSL SIGFANITGY SVISGLSMGM
121: EPICGQAYGA KQMKLLGLTL QRTVLLLLSC SVPISFSWLN MRRILLWCGQ DEEISSVAQQ
181: FLLFAIPDLF LLSLLHPLRI YLRTQNITLP VTYSTAVSVL LHVPLNYLLV VKLEMGVAGV
241: AIAMVLTNLN LVVLLSSFVY FTSVHSDTWV PITIDSLKGW SALLSLAIPT CVSVCLEWWW
301: YEFMIILCGL LANPRATVAS MGILIQTTAL VYVFPSSLSL GVSTRISNEL GAKRPAKARV
361: SMIISLFCAI ALGLMAMVFA VLVRHHWGRL FTTDAEILQL TSIALPIVGL CELGNCPQTT
421: GCGVLRGCAR PTLGANINLG SFYFVGMPVA ILFGFVFKQG FPGLWFGLLA AQATCASLML
481: CALLRTDWKV QAERAEELTS QTPGKSPPLL PIASSKSRST SGTEDMMRTM LV