2.A.66.1.57
DETOXIFICATION 41, DTX41, TDS3, TT12 of 507 aas and 12 TMSs. Acts as a flavonoid/H+-antiporter that controls the vacuolar sequestration of flavonoids in the seed coat endothelium (Debeaujon et al. 2001; Marinova et al. 2007). May also transport the anthocyanin cyanidin-3-O-glucoside (Marinova et al. 2007) and epicatechin 3'-O-glucoside (Zhao and Dixon 2009). These results have been confirmed in Daucus carota and other plants (Saad et al. 2023). A similar protein in Petunia hybrida, PhMATE1 transports antocyanins (flavanoids involved in flower color) and has 11 TMSs (Yuan et al. 2023). Soybean oil may facilitate interactions with flavonoids to form more stable and compact fatty acid-flavonoid complexes (Fu et al. 2024).
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| Accession Number: | Q9LYT3 |
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| Protein Name: | Protein DETOXIFICATION 41 |
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| Length: | 507 |
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| Molecular Weight: | 55147.00 |
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| Species: | Arabidopsis thaliana (Mouse-ear cress) [3702] |
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| Number of TMSs: | 12 |
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| Location1 / Topology2 / Orientation3: |
Vacuole membrane1 / Multi-pass membrane protein2 |
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| Substrate |
flavonoid, anthocyanin cation |
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1: MSSTETYEPL LTRLHSDSQI TERSSPEIEE FLRRRGSTVT PRWWLKLAVW ESKLLWTLSG
61: ASIVVSVLNY MLSFVTVMFT GHLGSLQLAG ASIATVGIQG LAYGIMLGMA SAVQTVCGQA
121: YGARQYSSMG IICQRAMVLH LAAAVFLTFL YWYSGPILKT MGQSVAIAHE GQIFARGMIP
181: QIYAFALACP MQRFLQAQNI VNPLAYMSLG VFLLHTLLTW LVTNVLDFGL LGAALILSFS
241: WWLLVAVNGM YILMSPNCKE TWTGFSTRAF RGIWPYFKLT VASAVMLCLE IWYNQGLVII
301: SGLLSNPTIS LDAISICMYY LNWDMQFMLG LSAAISVRVS NELGAGNPRV AMLSVVVVNI
361: TTVLISSVLC VIVLVFRVGL SKAFTSDAEV IAAVSDLFPL LAVSIFLNGI QPILSGVAIG
421: SGWQAVVAYV NLVTYYVIGL PIGCVLGFKT SLGVAGIWWG MIAGVILQTL TLIVLTLKTN
481: WTSEVENAAQ RVKTSATENQ EMANAGV