2.A.66.1.58
Detoxification-50, DTX50, of 505 aas and 12 TMSs. It catalyzes abscisic acid efflux and modulates ABA sensitivity as well as drought tolerance (Zhang et al. 2014). It may also function in heavy metal ion and drug export (Sailer et al. 2018; Li et al. 2002). Its ortholog in cucumber, the vacuolar MATE/DTX protein, exports cucurbitacin C, and its gene is co-regulated with bitterness biosynthesis in cucumber (Ma et al. 2023).
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| Accession Number: | Q9FJ87 |
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| Protein Name: | Protein DETOXIFICATION 50 |
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| Length: | 505 |
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| Molecular Weight: | 54970.00 |
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| Species: | Arabidopsis thaliana (Mouse-ear cress) [3702] |
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| Number of TMSs: | 12 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MSQSNRVRDE VTLPLLQKTS HLKNHSSVLS VFLNEAISIC KISYPLVLTG LFLYVRSFVS
61: LSFLGGLGDA TLAGGSLAAA FANITGYSLF SGLTMGVESI CSQAFGARRY NYVCASVKRG
121: IILLLVTSLP VTLLWMNMEK ILLILKQDKK LASEAHIFLL YSVPDLVAQS FLHPLRVYLR
181: TQSKTLPLSI CTVIASFLHL PITFFLVSYL GLGIKGIALS GVVSNFNLVA FLFLYICFFE
241: DKLSVNEDEK ITEETCEDSV REWKKLLCLA IPSCISVCLE WWCYEIMILL CGFLLDPKAS
301: VASMGILIQI TSLVYIFPHS LSLGVSTRVG NELGSNQPKR ARRAAIVGLG LSIALGFTAF
361: AFTVSVRNTW AMFFTDDKEI MKLTAMALPI VGLCELGNCP QTTGCGVLRG SARPKIGANI
421: NGVAFYAVGI PVGAVLAFWF GFGFKGLWLG MLAAQITCVI GMMAATCRTD WELEAERAKV
481: LTTAVDCGSS DDDAKEDMEA GMVDK