2.A.66.1.62
MATE family toxin extrusion protein 3 (Mate3/Slc47a2.1) of 590 aas and 13 TMSs in a 2 + 4 + 2 + 4 + 1 (C-terminal) TMSs. The 2 + 4 TMSs are repeated twice and comprise the usual 6 TMS repeat unit. its gene is highly expressed in the kidneys, intestine, testes, and brain of males. It interacts with xenobiotic compounds, suggesting a role in the efflux of toxic compounds (Vujica et al. 2023). These autors also showed that this porter interacts with and may export dozens of polutants in an aqueous environment.
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| Accession Number: | NP_001073648.1 |
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| Protein Name: | NP_001073648.1 multidrug and toxin extrusion protein 1 [Danio rerio] |
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| Length: | 591 |
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| Molecular Weight: | |
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| Species: | Danio rerio [7955] |
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| Number of TMSs: | 13 |
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| Substrate |
drug |
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1: MDSITSYNVT QMNGDTKQEK CDDVLSTSST QKFCGGCRKK LRSLLPVNYK TEIVELLKLA
61: GPVFISQLMI FLISFVSTVF CGHLGKTELA GVALAIAVIN VTGISIGSGL ASACDTLISQ
121: TFGSNNLKRV GVILQRGILI LLLACFPCWA LLINTEPILL AVRQSPNVAS LSQLYVKIFM
181: PALPAAFMYQ LQGRYLQNQG IIWPQVITGA AGNILNALIN YVFLHLLELG VAGSAAANTI
241: SQYSLAVFLY VYIRWKNLHK ATWDGWSRDC LQEWGAFIRL ALPSMLMLCV EWWTYEIGGF
301: LAGLISETEL GAQSVVYELA TIAYMFPLGF AVAASVRVGN ALGAGNTERA KLSAKVALVC
361: GVLVSCVVAT LIGCTKDVIA YIFTTEEEIV SRVSQVMIMY GFFHLFDAIA GITGGIVRGA
421: GKQLLGALCN IVGYYFVGFP TGVSLMFALS MGIIGLWIGF FGCVFLQSLF FIILIYKLDW
481: KKATQEALIR AGVQLTETKD ESFGLENKGC TEEAAKESQI TEEGLTDANT DLEGLSKGGE
541: GISEAGAKTT VGAVLTTKQL IVRRGLAVLL MVLILAGGIV LNEMLVRYLR