2.A.66.2.12
Isoprenoid lipid sugar glycan flippase, Wzx (note: Wzx forms a complex with Wzy and Wzz for assembly of periplasmic O-antigen) (Marolda et al., 2006). Wzx has a 12 TMS topology (Cunneen and Reeves, 2008). WzyE (450aas; 12 TMSs; TC#9.B.128.1.1; B614D1) is called the enterobacterial common antigen (ECA) polysaccharide chain elongation polymerase (Marolda et al., 2006). The structure of Wzz has been determined by cryoEM (Collins et al. 2017).
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| Accession Number: | Q1L811 |
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| Protein Name: | Wzx |
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| Length: | 411 |
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| Molecular Weight: | 46705.00 |
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| Species: | Escherichia coli [562] |
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| Number of TMSs: | 12 |
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| Location1 / Topology2 / Orientation3: |
Cell inner membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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| Pfam: |
PF01943
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[1] “A group of Escherichia coli and Salmonella enterica O antigens sharing a common backbone structure.” Wang W. et.al. 17600060
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1: MIKEIFSDGI FSLFNKICYF GFKTLAIILI TRSLGEDVGG EFIFLVGFLE VLRVVTDFGV
61: DLFVIKKYND STDKIKLLNV TFAQKILSGV IVLLLFCLYS FVQGYQYNVY IPIVLALPVA
121: LFFNFSNSYF QSLNSNKSLT FPIAIASIAT CTIFAIQYFL NVKFNAWDYL CVELLFVSLV
181: TLKLFVSVKF RFIRTSAFDV LMSILSLYKY TLSIGLTAVV VIIYSRIDNF YLKTFAPGDL
241: AAYGQIFRMV DPLVMVSSVF STVAYARFCR INLQEKNAFT KVFQFLLCIV AYGVLSSLVY
301: FFIIKYLGHF VLISNVNNDF LIMMFLIVAC VKCINGGTTA IIQSQGFYKV GLYVSYVCIL
361: TSIPTMYFLI MKYGVKGAAM TILLVECISF LLLLCSFFMI KKMRPKKTFE M