2.A.66.4.1
The mouse virulence factor, MviN. (May flip the Lipid II peptidoglycan precursor from the cytoplasmic side of the inner membrane to the periplasmic surface) (Vasudevan et al., 2009). MviN, a putative lipid flippase (Fay and Dworkin, 2009). In E. coli, MviN is an essential protein which when defective results in the accumulation of polyprenyl diphosphate-N-acetylmuramic acid-(pentapeptide)-N-acetyl-glucosamine. This may be the peptidoglycan intermediated exported via MviN (Inoue et al. 2008). It is essential for the growth of several bacteria.
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| Accession Number: | P37169 |
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| Protein Name: | MviN aka STM1170 |
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| Length: | 524 |
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| Molecular Weight: | 57315.00 |
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| Species: | Salmonella typhimurium [90371] |
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| Number of TMSs: | 14 |
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| Location1 / Topology2 / Orientation3: |
Cell inner membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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| RefSeq: |
NP_460141.1
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| Entrez Gene ID: |
1252688
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| Pfam: |
PF03023
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| BioCyc: |
STYP99287:STM1170-MONOMER
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| KEGG: |
stm:STM1170
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[1] “Sequence analysis of the flgA gene and its adjacent region in Salmonella typhimurium, and identification of another flagellar gene, flgN.” Kutsukake K. et.al. 8200538
[2] “Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.” McClelland M. et.al. 11677609
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1: MQEFYARVWN TKEMNLLKSL AAVSSMTMFS RVLGFARDAI VARIFGAGMA TDAFFVAFKL
61: PNLLRRIFAE GAFSQAFVPI LAEYKSKQGE EATRIFVAYV SGLLTLALAV VTVAGMLAAP
121: WVIMVTAPGF ADTADKFALT TQLLRITFPY ILLISLASLV GAILNTWNRF SIPAFAPTFL
181: NISMIGFALF AAPYFNPPVL ALAWAVTVGG VLQLVYQLPY LKKIGMLVLP RINFRDTGAM
241: RVVKQMGPAI LGVSVSQISL IINTIFASFL ASGSVSWMYY ADRLMEFPSG VLGVALGTIL
301: LPSLSKSFAS GNHDEYCRLM DWGLRLCFLL ALPSAVALGI LAKPLTVSLF QYGKFTAFDA
361: AMTQRALIAY SVGLIGLIVV KVLAPGFYSR QDIKTPVKIA IVTLIMTQLM NLAFIGPLKH
421: AGLSLSIGLA ACLNASLLYW QLRKQNIFTP QPGWMWFLMR LIISVLVMAA VLFGVLHIMP
481: EWSQGSMLWR LLRLMAVVIA GIAAYFAALA VLGFKVKEFV RRTA