2.A.66.4.8
MurJ (MviV) of 475 aas and 14 TMSs. Kuk et al. 2016 presented a
crystal structure of MurJ from Thermosipho africanus in an inward-facing conformation at 2.0-A
resolution. A hydrophobic groove is formed by two C-terminal transmembrane helices, which leads into
a large central cavity that is mostly cationic. Their results suggest that alternating access is important for MurJ function, which may
be applicable to other MOP superfamily transporters (Kuk et al. 2016).
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| Accession Number: | B7IE18 |
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| Protein Name: | Putative lipid II flippase MurJ |
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| Length: | 475 |
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| Molecular Weight: | 54091.00 |
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| Species: | Thermosipho africanus (strain TCF52B) [484019] |
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| Number of TMSs: | 14 |
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| Substrate |
|
|---|
1: MSILFSSILF SIATFFSRIL GLFRDVLFAK YFGVSYELDA YFIAIMFPFF LRKVFGEGAM
61: SSAFVPLYSE KSGEEKDKFL SSVINGFSLI ILALVILSYF FPELIINLFG AGSSHETKIL
121: AKKLLLITSP SIYFIFLWAI SYSILNTNNK FFWPALTPSI SNITIIIGTF LSTKYGIISP
181: TIGFLIGSIL MFFSIIKSII KHKYYFTIKH FPHFLKLFFP TFMTMVVSQI NTVVDMNVVS
241: FYDKGSISYL QYASRFYLLP YGLFAVSVST VVLSKISNDR KNFNYHLNDA LKTTLFFTIP
301: SMVGLIFLST PIIRFFYEHG AFTSKDTLIT SKILIAYTLG LPFYGIYSTI SRSYHAIKNT
361: KTPFIAATIV SLSNIILDII FGLKYGPIGV ALATSIAGII GVLYLLFSVK TFPIKDFLKI
421: SLNSLIMLFV IYLTDFTDNE FWFLIQILIG ILVYLIFSSI FYRDLIRRFL YARKK