TCDB is operated by the Saier Lab Bioinformatics Group

2.A.73 The Short Chain Fatty Acid Uptake (AtoE) Family

AtoE of E. coli has been examined topologically (Daley et al., 2005). It may transport short chain fatty acids into the E. coli cell (Salanitro and Wegener, 1971) although experimental characterisation is lacking.   Members of the AtoE derive from proteobacteria of the α-, β-, γ-, δ- and ε-subgroups, Bacteroidetes, Fusobacteria, Acidobacteria, Firmicutes, Actinobacteria and Archaea. They are of fairly uniform size (425-487 aas). Topological analyses of AtoE family members suggest 10 TMSs in a 5 + 5 arrangement. Phylogenetic analyses indicate that AtoE family members are diverse in function with several non-orthologous sets. Further, the tree suggests either that horizontal transfer or early gene duplication followed by selective loss of genetic material in some organisms has occurred (T.E. Verlhac and M.H. Saier, unpublished results).

The reaction presumed to be catalyzed by AtoE is:

short chain fatty acid (out) + H+ (out) → short chain fatty acid (in) + H+ (in)

References associated with 2.A.73 family:

Daley, D.O., M. Rapp, E. Granseth, K. Melen, D. Drew, and G. von Heijne. (2005). Global topology analysis of the Escherichia coli inner membrane proteome. Science 308: 1321-1323. 15919996
Jenkins, L.S. and W.D. Nunn. (1987). Genetic and molecular characterization of the genes involved in short-chain fatty acid degradation in Escherichia coli: the ato system. J. Bacteriol. 169: 42-52. 3025185
Matta, M.K., E.E. Lioliou, C.H. Panagiotidis, D.A. Kyriakidis, and C.A. Panagiotidis. (2007). Interactions of the antizyme AtoC with regulatory elements of the Escherichia coli atoDAEB operon. J. Bacteriol. 189: 6324-6332. 17616594
Salanitro, J.P. and W.S. Wegener. (1971). Growth of Escherichia coli on short-chain fatty acids: nature of the uptake system. J. Bacteriol. 108: 893-901. 4942769