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2.A.99.1.1
The highly specific Ni2+ uptake porter, HupE of 191 aas and 6 or 7 putative TMSs (Brito et al., 2010).  HupE is a medium-affinity and low-capacity transporter - its periplasmic region, 22HVGLHADGTLAGLN35, binds Ni2+ with much higher affinity than the transmembrane 36HPFSGLDH43 one, which transports the metal into the cell (Albareda et al. 2015). The specificity of the transmembrane region is similar to that of the periplasmic one and to that of the full-length HupE (Rowińska-Żyrek 2017).

Accession Number:P27650
Protein Name:Protein hupE
Length:191
Molecular Weight:19022.00
Species:Rhizobium leguminosarum bv. viciae [387]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate nickel(2+)

Cross database links:

Pfam: PF04955   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane

References (1)

[1] “Nucleotide sequence and characterization of four additional genes of the hydrogenase structural operon from Rhizobium leguminosarum bv. viciae.”  Hidalgo E.et.al.   1597428

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MKYSKITTTL AALALPSIAH AHVGLHADGT LAGLNHPFSG LDHILAMVAV GFWASTLGGK 
61:	AVWIVPSAFV IVMAGGGVLG IEGIALPMVE TAIALTVAML GLLVAFEVKI PTPVAAIVVG 
121:	ICALFHGHVH GIELPTMSNA TGYVAGFLAA TVILHVLGIG LASLRFGKAG QVVARVAGGA 
181:	VALAGAALLV G