TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
2.A.99.1.1









The highly specific Ni2+ uptake porter, HupE of 191 aas and 6 or 7 putative TMSs (Brito et al., 2010).  HupE is a medium-affinity and low-capacity transporter - its periplasmic region, 22HVGLHADGTLAGLN35, binds Ni2+ with much higher affinity than the transmembrane 36HPFSGLDH43 one, which transports the metal into the cell (Albareda et al. 2015). The specificity of the transmembrane region is similar to that of the periplasmic one and to that of the full-length HupE (Rowińska-Żyrek 2017).

Bacteria
Proteobacteria
HupE of Rhizobium leguminosarum (P27650)
2.A.99.1.2









The 6TMS Ni2+ uptake porter, HupE2 (Brito et al., 2010).

Bacteria
Proteobacteria
HupE2 of Rhizobium leguminosarum (Q1M8G8)
2.A.99.1.3









Urease accessory protein, UreJ

Bacteria
Proteobacteria
UreJ of Mesorhizobium loti (Q98CY5)
2.A.99.1.4









HupE/UreJ family protein of 217 aas and 7 TMSs

Bacteria
Cyanobacteria
UreJ of Microcystis aeruginosa
2.A.99.1.5









HupE/UreJ family protein of 223 aas and 7 TMSs

HupE of Flammeovirga pacifica
2.A.99.1.6









Uncharacterized protein of 252 aas and 7 C-terminal TMSs and an N-terminal hydrophilic domain.

Bacteria
Proteobacteria
UP of Niveispirillum sp. SYP-B3756
2.A.99.1.7









HupE/UreJ family protein of 185 aas and 7 TMSs.

Bacteria
Proteobacteria
HupE of Nitrincola tibetensis
2.A.99.1.8









Hydantoin utilization protein A of 214 aas and 7 TMSs.

Bacteria
Proteobacteria
HupE of Roseovarius litoreus