2.B.116.  The Tambjamine-containing Lipophilic Anioin Carrier (T-LAC) Family 

Six novel click-tambjamines (1-6) bearing an alkyl chain of varying lengths linked to the imine moiety have been formulated in nanostructured lipid carriers (NLCs) to evaluate their transmembrane anion transport activities, both when free (i.e., not encapsulated) and nanoformulated (Alonso-Carrillo et al. 2023). Nanostructured lipid carriers (NLCs) are an example of drug delivery systems (DDSs) that stand out because of their versatility.  Alonso-Carrillo et al. 2023 showed that NLCs can be used to efficiently formulate highly lipophilic anionophores, and experiments conducted in model liposomes revealed that these formulations are adequate to deliver anionophores without compromising their transport activity.