2.B.131.  The Pyridyl-linked Hetero Hydrazone - H+/Cl- Symporter (PHH-HCS) Family 

Pyridyl-linked hetero hydrazones are highly efficient transmembrane HCl symporters. These compounds offer an appropriate HCl binding site through cooperative protonation, followed by recognition of chloride ions. HCl transport by these compounds inhibits the growth of different Gram-negative bacterial strains with high efficacy by affecting the cell envelope homeostasis. This specific class of compounds holds substantial promise in the ongoing pursuit of developing highly efficient antibacterial agents (Mondal et al. 2024).