2.B.134.  The Solid Lipid Nanoparticle-Delivery System (SLN-DS) Family

Nanoparticle-based oral therapy allow enhancment of solubility, permeability and chemical stability of many drugs, especially of drugs poorly absorbed with an impairing coincidence of oral degradation. Solid lipid nanoparticles (SLNs), absorbed and trafficked via transcellular and paracellular pathways, are one of the  promising nanocarriers to overwhelm drawbacks of the poorly absorbed drugs. SLNs for improving drug oral absorption have been reviewed (Salah et al. 2020). The transversal mechanisms of SLNs across the gastrointestinal hurdles and in vitro protocols to uncover the investigations of the transmembrane absorption and transport kinetics of SLNs are also reviewed.