2.B.139.  The Coupled Photoresponsive Ion Transport with Transition Metal Catalysis          (CPIT-TMC) Family

The development of potent antibacterial agents has become increasingly difficult as bacteria continue to evolve and develop resistance to antibiotics. Using artificial transmembrane ion transporters is a promising avenue to address this issue. Mondal et al. 2024 reported pyridyl-linked hetero hydrazones as highly efficient transmembrane HCl symporters. These compounds offer an appropriate HCl binding site through cooperative protonation, followed by recognition of chloride ions. HCl transport by these compounds inhibits the growth of different Gram-negative bacterial strains with high efficacy by affecting the cell envelope homeostasis. This specific class of compounds holds substantial promise in the ongoing pursuit of  highly efficient antibacterial agents (Mondal et al. 2024).