2.B.40. The Monoacylglycerol Anion Carrier (MAG-AC) Family
Bahmanjah et al. 2012 showed that amphiphilic natural products, monoacylglycerols (see Fig 29 in Gale et al. 2017), function as transmembrane Cl-/NO3- anion exchange transporters. The 1,2-diol group proved to be crucial for transport function since diacylglycerol and triacylglycerol analogs were not anion transporters. Adding another hydrogen bond donor to the glycerol head-group and perfluorination of the acyl tail gave synthetic analogs with improved Cl- membrane transport properties with 20-fold better Cl-/NO3- antiport activity than the parental compound.