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2.B.48.  The Synthetic Transmembrane Ion Shuttling/Fishing (TISF) Family 

Ye et al. 2019 reported an 'ion-fishing' mechanism as an alternative to conventional carrier or channel mechanisms for mediating efficient and selective transmembrane K+ fluxes. The molecular framework underlying the fishing mechanism consists of a fishing rod, a fishing line and a fishing bait/hook, which encloses the ion to be transported across the membrane. It is simple but modularly modifiable. This feature enables rapid construction of a series of molecular ion fishers with different ion transport patterns. While more efficient ion transport is generally achieved by using 18-crown-6 as the fishing bait/hook, ions are transported selectivity since the K+/Na+ ratio depends on the length of the fishing line, with the most selective MF6-C14 exhibiting high selectivity (K+/Na+ = up to 18) and high activity.  Since the 'cage' inclosing the transported ion shuttles across the membrane, we classify this type of transport as a carrier-type rather than a channel-type.

References associated with 2.B.48 family:

Ye, R., C. Ren, J. Shen, N. Li, F. Chen, A. Roy, and H. Zeng. (2019). Molecular Ion Fishers as Highly Active and Exceptionally Selective K Transporters. J. Am. Chem. Soc. 141: 9788-9792. 31184884