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2.B.61. The Voltage-driven Flipping Zwitterionic Artificial Channel (VF-ZAC) Family 

Yan et al. 2021 developed a voltage-sensitive artificial transmembrane channel by mimicking the dipolar structure of the natural alamethicin channel. The artificial channel featured a zwitterionic structure and could undergo voltage-driven flipping in the lipid bilayers. This flipping of the channels could lead to their directional alignment in the bilayers and rectifying behavior for ion transport (Yan et al. 2021).

References associated with 2.B.61 family:

Yan, Z.J., Y.W. Li, M. Yang, Y.H. Fu, R. Wen, W. Wang, Z.T. Li, Y. Zhang, and J.L. Hou. (2021). Voltage-Driven Flipping of Zwitterionic Artificial Channels in Lipid Bilayers to Rectify Ion Transport. J. Am. Chem. Soc. 143: 11332-11336. 34270229