2.B.61. The Voltage-driven Flipping Zwitterionic Artificial Channel (VF-ZAC) Family
Yan et al. 2021 developed a voltage-sensitive artificial transmembrane channel by mimicking the dipolar structure of the natural alamethicin channel. The artificial channel featured a zwitterionic structure and could undergo voltage-driven flipping in the lipid bilayers. This flipping of the channels could lead to their directional alignment in the bilayers and rectifying behavior for ion transport (Yan et al. 2021).